Open Access Research article

A comparative transcriptomic, fluxomic and metabolomic analysis of the response of Saccharomyces cerevisiae to increases in NADPH oxidation

Magalie Celton12, Isabelle Sanchez1, Anne Goelzer2, Vincent Fromion2, Carole Camarasa1 and Sylvie Dequin1*

Author Affiliations

1 INRA, UMR1083 SPO, 2 place Viala, F-34060, Montpellier, France

2 INRA, MIG, F-78350, Jouy-en-Josas, France

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BMC Genomics 2012, 13:317  doi:10.1186/1471-2164-13-317

Published: 17 July 2012

Additional files

Additional file 1 :

Differentially expressed genes involved in the response to increases in NADPH and NADH oxidation. The differentially expressed genes involved in the response to increases in the oxidation of NADPH (100, 200 and 300 mM acetoin) and NADH (200 mM acetoin) are shown.

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Additional file 2 :

13 C-flux analysis:S. cerevisiae metabolic network, flux distribution in response to acetoin additions (0, 100, 200, 300 mM) and measured SFL and experimental data. (A) Reactions of the metabolic network used for 13 C-flux analysis. (B) Fluxes estimated by 13 C-flux analysis. (C) Measured SFL. (D) Specific growth rate, glucose uptake rates and yield coefficients used in 13 C flux.

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