Schematic illustration of the signaling pathway ofGHRregulated by let-7b. miRNA let-7b inhibits the expression of GHR and regulates SOCS3.SOCS3 regulates the growth and development of chickens through three signaling pathways: inhibiting the phosphorylation of tyrosine in IRS1; inhibiting LEPR; and inhibiting JAK. IRS1, LEPR and JAK are involved in growth, fat synthesis, and cell proliferation.
Lin et al. BMC Genomics 2012 13:306 doi:10.1186/1471-2164-13-306