Expression prediction accuracy for top 50 most variable genes across hematopoietic cell groups. Significance of expression prediction accuracy across hematopoietic cell types for K562 and GM12878 CRMs. We used CRMs to predict the expression of each gene in a cell type and calculated the mean squared prediction error from the observed expression. To test whether the prediction error is significantly low, we found the probability (p-value) of obtaining a prediction error just as low from using randomly generated CRMs to predict expression. Only the differentiated cell types are column labeled; left of each label are the columns for their progenitors.
Wang et al. BMC Genomics 2012 13:263 doi:10.1186/1471-2164-13-263