Expression prediction accuracy across terminally differentiated hematopoietic cells. Comparison of R2between observed and predicted expression in hematopoietic cell populations; erythroid cells (ERY5), megakaryocytes (MEGA2), neutrophils (GRAN3), monocytes (MONO2), eosinophils (EOS2), basophils (BASO1), myeloid dendritic cells (DENDA2), naive B cells (BCELLA1), mature NK cells (NK4), Naive CD8+ T cells (TCELLA2), and CD4+ effector memory T cells (TCELLA7). R2from expression models generated from K562 CRMs (red) are compared to models with TFs randomly selected from the 14 in K562 (green), and models generated from binding motifs of 41 TFs important to hematopoiesis (blue). Bars show 95% confidence intervals for the null models.
Wang et al. BMC Genomics 2012 13:263 doi:10.1186/1471-2164-13-263