Open Access Highly Accessed Research article

The immune gene repertoire of an important viral reservoir, the Australian black flying fox

Anthony T Papenfuss12, Michelle L Baker34*, Zhi-Ping Feng15, Mary Tachedjian3, Gary Crameri3, Chris Cowled3, Justin Ng3, Vijaya Janardhana3, Hume E Field67 and Lin-Fa Wang36*

Author Affiliations

1 Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, 3052, Australia

2 Department of Mathematics and Statistics, University of Melbourne, Melbourne, VIC, 3010, Australia

3 CSIRO Livestock Industries, Australian Animal Health Laboratory, PO Bag 24, Geelong, VIC, 3220, Australia

4 Center for Evolutionary and Theoretical Immunology, Department of Biology, The University of New Mexico, Albuquerque, NM, 87131, USA

5 Department of Medical Biology, University of Melbourne, Melbourne, VIC, 3010, Australia

6 Australian Biosecurity Cooperative Research Centre for Emerging Infectious Diseases, Brisbane, Australia

7 Queensland Primary Industries and Fisheries, Biosecurity Queensland, Brisbane, Australia

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BMC Genomics 2012, 13:261  doi:10.1186/1471-2164-13-261

Published: 20 June 2012

Additional files

Additional file 1:

Table S1. Summary of additive multiple-kmer velvet/oases/Mira3 assembly.

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Additional file 2:

Figure S1. Overview of the bat transcriptome. The distribution of 178,554 and 285,268 transcriptome sequences that have mapped to human orthologues from P. alecto thymus and pooled tissue datasets based on GO slim terms. Sequences within the three areas of Gene Ontology: molecular function, biological process and cellular component are further divided into subgroups at the GO Slim level.

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Additional file 3:

Sequences of all genes described in the manuscript.

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Additional file 4:

Figure 2. Amino acid composition of large unannotated ORFs. The horizontal axis shows amino acids sorted by flexibility index [88].a. Amino acid composition of 1656 large unannotated non-redundant ORFs relative to proteins in the SwissProt database [89]. The amino acids Trp, Cys and Pro have twice the abundance in unannotated ORFs compared to SwissProt proteins.b. Amino acid composition of 1195 low complexity regions in unannotated ORFs relative to 1656 unannotated non-redundant ORFs. Prolines are abundant in low complexity regions, but Trp and Cys are not.

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