Table 4

Key genes1related to breast muscle development or lipid metabolism in two breeds of chickens
Breed Symbol Gene Coefficient Regulation Trait
AA BMP2K BMP-2-inducible protein kinase −0.97 - Breast muscle
CAPNS1 Calpain, small subunit 1 1.00 +
GDF3 Growth differentiation factor 3 1.00 +
CH25H Cholesterol 25-hydroxylase 0.92 + PLIP
HMGCLL1 3-hydroxymethyl-3-methylglutaryl- Coenzyme A lyase-like 1 0.97 or 0.97 + TG or IMF
NACA Nascent polypeptide-associated complex alpha subunit −1.00 - PLIP
RBP7 Retinol binding protein 7 −0.95 - PLIP

RCJMB04

_10b24

membrane bound O-acyltransferase domain containing 1.00 + PLIP

RCJMB04

_13o20

NSFL1 (p97) cofactor (p47) 1.00 + PLIP
SGPL1 Sphingosine-1-phosphate lyase 1 −1.00 or −1.00 - TG or IMF
SH3PXD2B SH3 and PX domains 2B −0.95 or −0.96 - TG or IMF
SNX3 Sorting nexin 3 0.96 + PLIP
THBS1 Thrombospondin-1 1.00 or 1.00 + TG or IMF
THRSP Thyroid hormone responsive, SPOT14 homolog −0.86 or −0.85 - TG or IMF
UCP3 Uncoupling protein 3 1.00 or 1.00 + TG or IMF
BJY ANKRD1 Ankyrin repeat domain 1 0.94 + Breast muscle
CENPF Centromere protein F −0.77 -
ELN Elastin −0.92 -
FGF7 Fibroblast growth factor 7 −0.99 -
FGFR1 Fibroblast growth factor receptor 1 −0.98 -
PLG Plasminogen 0.96 +
MYBL2 V-myb myeloblastosis viral oncogene homolog (avian)-like 2 −0.97 -
MYCN V-myc myelocytomatosis viral related oncogene, neuroblastoma derived −0.94 -
YWHAH Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein 0.99 + PLIP
NR3C2 Nuclear receptor subfamily 3, group C, member 2 0.95 + PLIP
LOC416618 NAD(P) dependent steroid dehydrogenase-like −0.74 - PLIP
EHHADH Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase 0.90 or 0.85 + TG or IMF
ETFDH Electron-transferring-flavoprotein dehydrogenase −0.95 - PLIP
AA/BJY2 MYBPC1 Myosin binding protein C, slow type 0.96/0.96 + Breast muscle
CETP Cholesteryl ester transfer protein 0.98/0.80 + PLIP
GLTPD1 Glycolipid transfer protein domain containing 1 −1.00/-0.96 - PLIP
SNX4 Sorting nexin 4 0.95/1.00 or 0.94/0.90 + TG or IMF

All correlations were significant (p < 0.05 or p < 0.01). 1Key gene were defined as its expression determined by microarray was significantly correlated (p < 0.05 or p < 0.01) with changes in breast muscle weight or in content of IMF, TG or PLTP across the sampled ages. 2Common to both BJY and AA breeds, the expression of genes was significantly correlated with target traits across ages. “+” represents up-regulated effect; “-” represents down-regulated effect. d = day. IMF, Intramuscular fat; TG, Triglyceride; PLIP, Phospholipids; BJY, Beijing-you; AA, Arbor Acres.

Cui et al.

Cui et al. BMC Genomics 2012 13:213   doi:10.1186/1471-2164-13-213

Open Data