Table 4

Predicted heme and cobalamin biosynthesis genes on theG. lovleyistrain SZ genome in comparison to the model organism for anaerobic cobalamin biosynthesis,Salmonella entericasubsp.entericaser. Typhimurium
G. lovleyi SZ genome Homolog in Salmonella enterica subsp. enterica ser. Typhimurium LT2
Chromosome Plasmid pSZ77 Gene symbol Function % Ident. (%Simil.)
Chr.#pSZ77
Early heme biosynthesis Glov_0501 hemD Uroporphyrinogen-III synthase no match
Glov_0502 hemC Porphobilinogen deaminase 52(65)
Glov_0503 hemA Glutamyl-tRNA reductase 40(62)
Glov_0688 hemB δ-Aminolevulinic acid dehydratase 47(63)
Late heme biosynthesis Glov_0521 hemY Protoporphyrinogen oxidase no match
Glov_1228 hemN Coproporphyrinogen III oxidase 27(45)
Glov_2930 hemH Ferrochelatase 31(47)
Glov_3245 hemL Uroporphyrinogen decarboxylase 52(67)
Cobalamin biosynthesis Glov_3417 Glov_3646 cbiE Precorrin-6y C5,15-methyl-transferase 32(54)35(57)
Glov_3647 cbiJ Precorrin-6x reductase 30(44)
Glov_3648 cbiH Precorrin-3B C17-methyltransferase 46(63)
Glov_3649 cbiG Cobalamin biosynthesis protein 31(49)
Glov_3650 cbiF Precorrin-4 C11-methyltransferase 50(68)
Glov_3651 cbiD Cobalamin biosynthesis protein 35(51)
Glov_3652 cbiL Precorrin-2 C20-methyltransferase 33(52)
Glov_3653 cbiK Anaerobic cobalt chelatase 32(45)
Glov_3654 cbiC Precorrin-8X methylmutase 34(52)
Glov_3655 cbiA Cobyrinic acid a,c-diamide synthase 39(55)
Glov_3656 sirA/cysG Siroheme synthase/ uroporphyrin-III C-methyltransferase 41(57)/40(57)
Glov_2767 Glov_3657 cbiO Cobalt ABC transporter, ATPase subunit 38(54) 35(56)
Glov_2768 Glov_3658 cbiQ Cobalt ABC transporter, inner membrane subunit 26(44) 23(45)
Glov_3659 cbiN Cobalt transport protein 42(57)
Glov_2769 Glov_3660 cbiM Cobalt transport protein 35(48) 54(68)
Glov_0692 Glov_3718 cobA Corrinoid:ATP adenosyltransferase 36(54) 46(67)
Glov_3081 cobU Bifunctional adenosylcobinamide kinase /adenosylcobinamide-phosphate guanylyltransferase 45(57)
Glov_3082* Glov_3678 cobT Nicotinate-nucleotide-DMBA-phosphoribosyltransferase 38(57) 39(57)
Glov_3083 cobS Cobalamin synthase 35(51)
Glov_3084 cobC α-Ribazole-5'-phosphate phosphatase 25(43)
Glov_3417 cbiT Precorrin decarbocylase 33(54)
Glov_3553 cbiB Cobalamin biosynthesis protein 46(62)
Glov_3554* Glov_3679 cobD/cbiP L-threonine O-3-phosphate decarboxylase/ cobyric acid synthase 34(51)/45(63)
45(62)/35(51)

# Chr. = chromosome.

* SZ chromosomal cobT and cobD/cbiP share 78% and 77% identity with their respective pSZ77 paralogs.

Wagner et al.

Wagner et al. BMC Genomics 2012 13:200   doi:10.1186/1471-2164-13-200

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