Gene Set Enrichment Analysis with stress- and reproduction-related gene sets. We applied GSEA to test whether the reproduction- and stress- gene sets are enriched in the rank-ordered list of genes for the comparison between C and SR flies. For each test, GSEA provides an enrichment score (ES) that measures the degree of enrichment of the gene set at the top or bottom of a rank-ordered gene list derived from the data set. A nominal P value was used to assess the significance of the ES. Vertical lines indicate the position of each of the genes comprising the stress and reproduction gene set. The figure panels show the plots of the running sum for the two gene sets: (A) reproduction and (B) stress gene set, respectively.
Doroszuk et al. BMC Genomics 2012 13:167 doi:10.1186/1471-2164-13-167