Open Access Highly Accessed Research article

The stable traits of melanoma genetics: an alternate approach to target discovery

Tara L Spivey123, Valeria De Giorgi115*, Yingdong Zhao4, Davide Bedognetti156, Zoltan Pos7, Qiuzhen Liu1, Sara Tomei18, Maria Libera Ascierto159, Lorenzo Uccellini112, Jennifer Reinboth11314, Lotfi Chouchane10, David F Stroncek11, Ena Wang1 and Francesco M Marincola115*

Author Affiliations

1 Infectious Disease and Immunogenetics Section (IDIS), Department of Transfusion Medicine, Clinical Center and trans-NIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, MD 20892, USA

2 Clinical Research Training Program (CRTP), National Institutes of Health, Bethesda, MD 20892, USA

3 Rush University Medical Center, Rush Medical College, Chicago, IL 60612, USA

4 Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

5 Department of Internal Medicine (DiMI), University of Genoa, Viale Benedetto XV,6, 16132 Genoa, Italy

6 Department of Oncology, Biology and Genetics and National Cancer Research Institute of Genoa, Genoa, Italy

7 Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest H-1089, Hungary

8 Department of Oncology, University of Pisa, Pisa, Italy

9 Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy

10 Weill Cornell Medical College in Qatar, Education City, P.O. Box 24144, Doha, Qatar

11 Cell Processing Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA

12 Institute of Infectious and Tropical Diseases, University of Milan, L. Sacco Hospital, Milan, Italy

13 Genelux Corporation, San Diego Science Center, San Diego, CA, USA

14 Department of Biochemistry, Biocenter, University of Würzburg, D-97074 Würzburg, Germany

15 Infectious Disease and Immunogenetics Section (IDIS), Department of Transfusion Medicine, Clinical Center and Center for Human Immunology (CHI), National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA

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BMC Genomics 2012, 13:156  doi:10.1186/1471-2164-13-156

Published: 26 April 2012

Additional files

Additional file 1:

Figure S1. Shows self-organizing heat map comparing the distribution of molecularly matched TM (green)/CM (yellow) pairs based on 109 transcripts selected from common cancer biomarkers [27], melanoma restricted genes [26], cancer testis antigens [42] and melanoma differentiation antigens [43]. Autologous samples are color coded according to "sample ID".

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Additional file 2:

Table S1. Is a table listing the 3,030, 1,006 transcripts stably expressed by CMs and TMs and the 968 genomics delegates.

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Additional file 3:

Table S2. Is a table listing a number of identified housekeeping genes selected according to the two referred paper [28,29].

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Additional file 4:

Figure S2. Shows Self-organizing heat map genes of 112 melanoma metastases based on the expression of melanoma differentiation antigens and representative cancer testis antigens.

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Additional file 5:

Table S3. Is a table listing selected gene-specific sequencing and CGH results of cell lines ranked according to the inclusion of their parental tumors into the three different TARA's classes.

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