Table 11

List of genes with altered expression according to microarray analysis related to KEGG pathway of Parkinson's disease

KEGG

Human

embryo

larvae

Flybase

name

gene

o.ex.

mut.

o.ex.

mut.

ID

Description


TH

TH

up

CG10118

pale, tyrosine hydroxylase


VMAT

VMAT

up

CG6139

vesicular monoamine transporter


DAT

SCL6A3

up

down

CG8380

dopamine transporter


HTRA2

HTRA2

up

down

CG8464

HtrA serine peptidase 2


NDUFV1

NDUFV1

up

down

CG9140

NADH dehydrogenase


SNCAIP

SNCAIP

up

down

CG5424

forked, actin binding α synuclein interacting


CDCREL1

PNUTL1

up

down

CG7238

septin interacting protein 1


CytC

CYCS

up

down

CG14235

cytochrome-c oxidase


UQCRH

UQCRH

up

up

down

CG30354

ubiquinol-cytochrome-c reductase


SIP2

up

down

CG9188

septin interacting protein 2


SLC25A6

up

down

CG1683

mitochondrial adenine nucleotide translocase 2


Uchl1

UCHL

up

CG4265

Ubiquitin carboxy-terminal hydrolase


mPTP

VDAC2

up

up

up

down

CG17137

Porin2, voltage-gated anion channel


ATPase

ATP5EP2

up

CG31477

mitochondrial ATPase ε subunit, F1 complex


NDUFA2

NDUFA2

up

up

CG15434

NADH dehydrogenase


SEP4

up

up

CG9699

Septin 4


Ube2J2

UBE2J2

down

up

CG5823

ubiquitin-protein ligase


NDUFV2

NDUFV2

up

CG5707

NADH dehydrogenase


UBE2H

up

CG2257

Ubc-E2H, ubiquitin-protein ligase


Ube2L3

UBE2L3

down

down

CG12799

Ubiquitin conjugating enzyme 84D


UBQLN1

down

CG14224

EF1B ubiquitin-assoc. translation elongation factor


Ubh4

UCHL

down

CG3431

Ubiquitin C-terminal hydrolase


USP36

down

CG5505

scrawny, ubiquitin protease


SIP3

down

CG1937

septin interacting protein 3


Uba1

UBA1

up

CG1782

ubiquitin activating enzyme 1


CytC

CYCS

up

up

CG2249

cytochrome-c oxidase


SEP1

up

CG1403

Septin-1


UBE2E2

up

CG6720

Ubiquitin conjugating enzyme 2


DJ-1

DJ-1

down

CG6646

DJ-1α


CytC

CYCS

down

CG13263

cytochrome c distal


CytC

CYCS

down

CG14028

cyclope, cytochrome-c oxidase


CytC

CYC1

down

CG4769

electron transporter


ATPase

ATP5G2

down

down

CG1746

hydrogen-exporting ATPase


ATPase

ATP5E

down

CG9032

stunted, hydrogen-exporting ATPase


Significant alterations in gene expression from wild type are shown by word code; "up" represents upregulation and "down" downregulation of gene expression. Notice that the same KEGG identifier can lead to several different genes. Several Drosophila genes associated with processes in PD missing from KEGG pathway were added. The according coloured scheme for Parkinson's disease KEGG pathway is presented in Figure 5.

Palgi et al. BMC Genomics 2012 13:134   doi:10.1186/1471-2164-13-134

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