Table 10

List of genes with altered expression according to microarray analysis related to KEGG lysosome pathway

KEGG

Gene

embryo

larvae

name

name

o.ex.

mut.

o.ex.

mut.

Description


AGA

CG10474

down

down

N4-(beta-N-acetylglucosaminyl)-L-asparaginase


SGSH

CG14291

up

down

N-sulfoglucosamine sulfohydrolase


AP-3

cm

up

down

carmine


ARS

CG7402

down

down

down

arylsulfatase B


ATPeV

CG7678

down

up

down

V-type H+-transporting ATPase subunit I


ATPeV

Vha100-1

up

down

Vha100-1


ATPeV

VhaSFD

down

Vacuolar H[+]-ATPase SFD subunit


cystinosin

CG17119

up

down

cystinosin


GUSB

CG2135

up

down

beta-glucuronidase


cathepsin

cathD

down

cathepsin D, pepsin A


LAMAN

CG6206

up

down

lysosomal alpha-mannosidase


CLN3

cln3

down

cln3


GLA

CG7997

down

alpha-galactosidase


ATPeV

Vha16

down

up

Vacuolar H[+] ATPase 16kD subunit


LYPLA3

CG31683

down

down

up

lysophospholipase III


CLN1

Ppt2

up

down

down

up

Palmitoyl-protein thioesterase 2


LAMAN

CG5322

up

down

down

up

lysosomal alpha-mannosidase


LYMP

trpml

down

down

up

control of membrane trafficking of proteins and lipids


NAGA

CG5731

up

down

up

up

alpha-N-acetylgalactosaminidase


LIMP

Tsp39D

down

up

Tetraspanin 39D


LIMP

Tsp29Fa

down

up

Tetraspanin 29Fa


HGSNAT

CG6903

down

up

heparan-alpha-glucosaminide N-acetyltransferase


saposin

Sap-r

down

up

Saposin-related


cathepsin

cathF

down

up

cathepsin F


LAMAN

CG9466

down

up

lysosomal alpha-mannosidase


LAMAN

CG9463

down

up

lysosomal alpha-mannosidase


AP-3

g

down

up

garnet, adaptor-related protein complex 3


clathrin

Chc

down

up

Clathrin heavy chain


GLB

CG9092

up

up

up

up

beta galactosidase


GTPase

Gie

up

N-terminally acetylated Arf-like GTPase


LAMAN

CG9465

up

lysosomal alpha-mannosidase


GBA

CG31148

up

up

up

glucosylceramidase


cathepsin

cathL

up

up

cathepsin L


GNS

CG18278

up

up

N-acetylglucosamine-6-sulfatase


GGA

Gga

up

up

Gga


AP-1

AP-1s

up

up

AP-1sigma


cathepsin

Cp1

up

up

Cysteine proteinase-1


LYMP

spin

up

up

spinster, lysosomal turnover regulator


GNS

CG30059

up

N-acetylglucosamine-6-sulfatase


Significant alterations in gene expression from wild type are shown by word code; "up" represents upregulation and "down" downregulation of gene expression. ID stands for the particular homologue gene name in Drosophila. Notice that the same KEGG identifier can lead to several different genes. The according coloured scheme for lysosome KEGG pathway is presented in Additional File 9.

Palgi et al. BMC Genomics 2012 13:134   doi:10.1186/1471-2164-13-134

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