Table 4 |
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|
The 50 PFAM categories most expanded in the Mycobacteria relative to the non- Mycobacteria |
|||
|
PFAM descriptor |
PFAM ID |
p-valuea |
inter-to-intra centroid difference |
|
|
|||
|
e Protein of unknown function (DUF2599) |
PF10783 |
1.50E-10 |
8.80E+00 |
|
|
|||
|
c Cutinase |
PF01083 |
1.60E-10 |
1.50E+01 |
|
|
|||
|
e Uncharacterized protein conserved in bacteria (DUF2236) |
PF09995 |
2.20E-10 |
1.60E+01 |
|
|
|||
|
c Lpp-LpqN Probable lipoprotein LpqN |
PF10738 |
4.70E-10 |
1.30E+01 |
|
|
|||
|
e Domain of unknown function (DUF385) |
PF04075 |
5.70E-10 |
1.30E+01 |
|
|
|||
|
b Domain of unk function DUF140 (yrbE genes in mce operons) |
PF02405 |
1.60E-09 |
1.40E+01 |
|
|
|||
|
Retinal pigment epithelial membrane protein |
PF03055 |
8.50E-09 |
1.40E+01 |
|
|
|||
|
e Domain of unknown function (DUF427) |
PF04248 |
1.40E-08 |
1.60E+01 |
|
|
|||
|
ABC transporter transmembrane region 2 PF06472 |
PF06472 |
1.80E-08 |
1.10E+01 |
|
|
|||
|
b Peroxidase (katG-isoniazid resistance) |
PF00141 |
4.10E-08 |
1.20E+01 |
|
|
|||
|
b mce related protein |
PF02470 |
1.30E-07 |
1.30E+01 |
|
|
|||
|
N O-methyltransferase N-terminus |
PF02409 |
1.70E-07 |
1.70E+01 |
|
|
|||
|
Activator of Hsp90 ATPase homolog 1-like protein |
PF08327 |
2.40E-07 |
1.10E+01 |
|
|
|||
|
Coronavirus nonstructural protein NS1 |
PF06145 |
3.00E-07 |
1.20E+01 |
|
|
|||
|
e Predicted integral membrane protein (DUF2189) |
PF09955 |
3.10E-07 |
1.40E+01 |
|
|
|||
|
e Uncharacterized protein family (UPF0089) |
PF03007 |
3.80E-07 |
1.50E+01 |
|
|
|||
|
b Acetyltransf 2 N-acetyltransferase (inactivates isoniazid) |
PF00797 |
3.90E-07 |
1.70E+01 |
|
|
|||
|
e Domain of unknown function (DUF1957) |
PF09210 |
5.50E-07 |
7.90E+00 |
|
|
|||
|
KRAB box |
PF01352 |
7.00E-07 |
1.70E+01 |
|
|
|||
|
Prokaryotic acetaldehyde dehydrogenase, dimerisation |
PF09290 |
8.10E-07 |
9.00E+00 |
|
|
|||
|
DmpG-like communication domain |
PF07836 |
9.50E-07 |
1.10E+01 |
|
|
|||
|
Nuclear transport factor 2 (NTF2) domain |
PF02136 |
1.00E-06 |
1.30E+01 |
|
|
|||
|
Wyosine base formation |
PF08608 |
1.10E-06 |
1.40E+01 |
|
|
|||
|
AIG2-like family |
PF06094 |
1.30E-06 |
1.80E+01 |
|
|
|||
|
e Protein of unknown function (DUF867) |
PF05908 |
1.30E-06 |
1.50E+01 |
|
|
|||
|
Phage-related minor tail protein |
PF10145 |
2.10E-06 |
1.20E+01 |
|
|
|||
|
c Fatty acid desaturase |
PF03405 |
2.30E-06 |
1.00E+01 |
|
|
|||
|
PaaX-like protein |
PF07848 |
2.80E-06 |
1.50E+01 |
|
|
|||
|
Adenylate and Guanylate cyclase catalytic domain |
PF00211 |
3.70E-06 |
1.10E+01 |
|
|
|||
|
Fibronectin-attachment protein (FAP) |
PF07174 |
3.80E-06 |
1.30E+01 |
|
|
|||
|
Leucine Rich Repeat |
PF07723 |
5.50E-06 |
1.10E+01 |
|
|
|||
|
2-nitropropane dioxygenase |
PF03060 |
5.70E-06 |
1.40E+01 |
|
|
|||
|
c Fatty acid desaturase |
PF00487 |
7.90E-06 |
1.30E+01 |
|
|
|||
|
e Protein of unknown function (DUF732) |
PF05305 |
9.10E-06 |
1.50E+01 |
|
|
|||
|
c Enoyl-CoA hydratase/isomerase family |
PF00378 |
9.70E-06 |
1.10E+01 |
|
|
|||
|
arg-2/CPA1 leader peptide |
PF08252 |
1.00E-05 |
1.40E+01 |
|
|
|||
|
c alpha/beta hydrolase fold (lipases) |
PF07859 |
1.10E-05 |
1.50E+01 |
|
|
|||
|
Cytochrome P450 |
PF00067 |
1.40E-05 |
1.20E+01 |
|
|
|||
|
c Cyclopropane-fatty-acyl-phospholipid synthase PF02353 |
PF02353 |
1.60E-05 |
1.20E+01 |
|
|
|||
|
Isoprenylcysteine carboxyl methyltransferase (ICMT) family |
PF04140 |
1.90E-05 |
1.50E+01 |
|
|
|||
|
Hydratase/decarboxylase |
PF01689 |
2.50E-05 |
6.60E+00 |
|
|
|||
|
PsbJ |
PF01788 |
3.00E-05 |
9.40E+00 |
|
|
|||
|
Linocin M18 bacteriocin protein |
PF04454 |
3.40E-05 |
1.60E+01 |
|
|
|||
|
Extensin-like protein repeat |
PF02095 |
4.00E-05 |
1.50E+01 |
|
|
|||
|
5HT transporter Serotonin (5-HT) neurotransmitter transporter, N-terminus |
PF03491 |
4.00E-05 |
9.50E+00 |
|
|
|||
|
e Protein of unknown function (DUF571) |
PF04600 |
4.20E-05 |
7.70E+00 |
|
|
|||
|
Tryptophyllin-3 skin active peptide |
PF08248 |
4.90E-05 |
1.50E+01 |
|
|
|||
|
AMP-binding enzyme |
PF00501 |
8.10E-05 |
9.20E+00 |
|
|
|||
|
e Bacterial protein of unknown function (DUF853) |
PF05872 |
9.90E-05 |
1.30E+01 |
|
|
|||
|
c Acyl-ACP thioesterase |
PF01643 |
1.10E-04 |
1.10E+01 |
|
|
|||
|
aBonferroni-corrected p-value calculated from T-test b pathogenicity or survival within the host c Lipid metabolism d Cofactor biosynthesis e unknown function |
|||
|
McGuire et al. BMC Genomics 2012 13:120 doi:10.1186/1471-2164-13-120 |
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