Table 4

The 50 PFAM categories most expanded in the Mycobacteria relative to the non- Mycobacteria

PFAM descriptor

PFAM ID

p-valuea

inter-to-intra centroid difference


e Protein of unknown function (DUF2599)

PF10783

1.50E-10

8.80E+00


c Cutinase

PF01083

1.60E-10

1.50E+01


e Uncharacterized protein conserved in bacteria (DUF2236)

PF09995

2.20E-10

1.60E+01


c Lpp-LpqN Probable lipoprotein LpqN

PF10738

4.70E-10

1.30E+01


e Domain of unknown function (DUF385)

PF04075

5.70E-10

1.30E+01


b Domain of unk function DUF140 (yrbE genes in mce operons)

PF02405

1.60E-09

1.40E+01


Retinal pigment epithelial membrane protein

PF03055

8.50E-09

1.40E+01


e Domain of unknown function (DUF427)

PF04248

1.40E-08

1.60E+01


ABC transporter transmembrane region 2 PF06472

PF06472

1.80E-08

1.10E+01


b Peroxidase (katG-isoniazid resistance)

PF00141

4.10E-08

1.20E+01


b mce related protein

PF02470

1.30E-07

1.30E+01


N O-methyltransferase N-terminus

PF02409

1.70E-07

1.70E+01


Activator of Hsp90 ATPase homolog 1-like protein

PF08327

2.40E-07

1.10E+01


Coronavirus nonstructural protein NS1

PF06145

3.00E-07

1.20E+01


e Predicted integral membrane protein (DUF2189)

PF09955

3.10E-07

1.40E+01


e Uncharacterized protein family (UPF0089)

PF03007

3.80E-07

1.50E+01


b Acetyltransf 2 N-acetyltransferase (inactivates isoniazid)

PF00797

3.90E-07

1.70E+01


e Domain of unknown function (DUF1957)

PF09210

5.50E-07

7.90E+00


KRAB box

PF01352

7.00E-07

1.70E+01


Prokaryotic acetaldehyde dehydrogenase, dimerisation

PF09290

8.10E-07

9.00E+00


DmpG-like communication domain

PF07836

9.50E-07

1.10E+01


Nuclear transport factor 2 (NTF2) domain

PF02136

1.00E-06

1.30E+01


Wyosine base formation

PF08608

1.10E-06

1.40E+01


AIG2-like family

PF06094

1.30E-06

1.80E+01


e Protein of unknown function (DUF867)

PF05908

1.30E-06

1.50E+01


Phage-related minor tail protein

PF10145

2.10E-06

1.20E+01


c Fatty acid desaturase

PF03405

2.30E-06

1.00E+01


PaaX-like protein

PF07848

2.80E-06

1.50E+01


Adenylate and Guanylate cyclase catalytic domain

PF00211

3.70E-06

1.10E+01


Fibronectin-attachment protein (FAP)

PF07174

3.80E-06

1.30E+01


Leucine Rich Repeat

PF07723

5.50E-06

1.10E+01


2-nitropropane dioxygenase

PF03060

5.70E-06

1.40E+01


c Fatty acid desaturase

PF00487

7.90E-06

1.30E+01


e Protein of unknown function (DUF732)

PF05305

9.10E-06

1.50E+01


c Enoyl-CoA hydratase/isomerase family

PF00378

9.70E-06

1.10E+01


arg-2/CPA1 leader peptide

PF08252

1.00E-05

1.40E+01


c alpha/beta hydrolase fold (lipases)

PF07859

1.10E-05

1.50E+01


Cytochrome P450

PF00067

1.40E-05

1.20E+01


c Cyclopropane-fatty-acyl-phospholipid synthase PF02353

PF02353

1.60E-05

1.20E+01


Isoprenylcysteine carboxyl methyltransferase (ICMT) family

PF04140

1.90E-05

1.50E+01


Hydratase/decarboxylase

PF01689

2.50E-05

6.60E+00


PsbJ

PF01788

3.00E-05

9.40E+00


Linocin M18 bacteriocin protein

PF04454

3.40E-05

1.60E+01


Extensin-like protein repeat

PF02095

4.00E-05

1.50E+01


5HT transporter Serotonin (5-HT) neurotransmitter transporter, N-terminus

PF03491

4.00E-05

9.50E+00


e Protein of unknown function (DUF571)

PF04600

4.20E-05

7.70E+00


Tryptophyllin-3 skin active peptide

PF08248

4.90E-05

1.50E+01


AMP-binding enzyme

PF00501

8.10E-05

9.20E+00


e Bacterial protein of unknown function (DUF853)

PF05872

9.90E-05

1.30E+01


c Acyl-ACP thioesterase

PF01643

1.10E-04

1.10E+01


aBonferroni-corrected p-value calculated from T-test

b pathogenicity or survival within the host

c Lipid metabolism

d Cofactor biosynthesis

e unknown function

McGuire et al. BMC Genomics 2012 13:120   doi:10.1186/1471-2164-13-120

Open Data