Functional interaction network analysis of genes with enriched expression (EE) and differential splicing (DS) in the placenta. Shown is module 0 of the interaction network constructed for chorion. Circular node: a query gene. Diamond-shaped node: a linker gene. Node color was determined based on whether the query gene shows EE (green), DS (pink), or both (red). Two large circular clusters represent highlighted significantly enriched pathways in chorion: glypican, SMAD2/3, and TGF-beta receptor signaling pathways (left-hand side; red lines) and HIF-1 alpha transcription factor signaling pathway (right-hand side; blue lines). FOS and SERPINE1 are shared by both groups of enriched pathways, but only shown in the right cluster. Several linker hub genes with dense connections with the highlighted pathways are also shown in bigger nodes.
Kim et al. BMC Genomics 2012 13:115 doi:10.1186/1471-2164-13-115