Table 1

Network characteristics of hub proteins in 3 categories.

Type

Average clustering coefficient

Average betweenness centrality (10-4)


Category 1 (41 hubs)

0.231 ±0.017*

5.56 ±0.53

Category 2 (264 hubs)

0.099 ±0.016

36.32 ±2.41

Category 3 (315 hubs)

0.154 ±0.004

10.91 ±2.79


Average clustering coefficient and betweenness centrality for 3 categories of hubs based on co-expression correlation and stability. Category 1 – correlation > 0.5, stability > 0.5; Category 2 – correlation <= 0.5, stability > 0.5; Category 3 – correlation <= 0.5, stability <= 0.5. Differences in the distributions of Hub categories 1, 2 and 2, 3 are statistically significant at p << 0.001.

* 95% confidence intervals for average clustering coefficient and betweenness centrality for hubs in each category.

Patil et al. BMC Genomics 2011 12(Suppl 3):S19   doi:10.1186/1471-2164-12-S3-S19

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