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This article is part of the supplement: Selected articles from the IEEE International Conference on Bioinformatics and Biomedicine 2010

Open Access Proceedings

CAMBer: an approach to support comparative analysis of multiple bacterial strains

Michal Wozniak12*, Limsoon Wong2 and Jerzy Tiuryn1

Author affiliations

1 Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Poland

2 School of Computing, National University of Singapore, Singapore

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Citation and License

BMC Genomics 2011, 12(Suppl 2):S6  doi:10.1186/1471-2164-12-S2-S6

Published: 27 July 2011

Abstract

Background

There is a large amount of inconsistency in gene structure annotations of bacterial strains. This inconsistency is a frustrating impedance to effective comparative genomic analysis of bacterial strains in promising applications such as gaining insights into bacterial drug resistance.

Results

Here, we propose CAMBer as an approach to support comparative analysis of multiple bacterial strains. CAMBer produces what we called multigene families. Each multigene family reveals genes that are in one-to-one correspondence in the bacterial strains, thereby permitting their annotations to be integrated. We present results of our method applied to three human pathogens: Escherichia coli, Mycobacterium tuberculosis and Staphylococcus aureus.

Conclusions

As a result, more accurate and more comprehensive annotations of the bacterial strains can be produced.