Table 5

Associations of 32 bimodal genes with cis-determining SNPs and reported CNV.

Bimodality

confirmed

in all

data sets

Gene

symbol

SNP association

with expression

p-vala

Kappa

coeff.

# of SNPs

within 200 KB

Reported CNVb


Yes

GSTM1

1.20E-11

0.65

36

Yes


Yes

HLA-DRB1

<1E-16

0.83

119

Yes


Yes

ERAP2

<1E-16

0.85

94

No


Yes

HLA-DRB5

2.12E-14

0.86

104

Yes


Yes

MAOA

<1E-16

0.80

69

No


Yes

ACTN3

<1E-16

0.90

9

No


MEIS2

0.04

0.17

86

No


TMEM70

<1E-16

0.39

76

No


SLC44A5

<1E-16

0.74

112

Yes


Yes

NR4A2

0.26

0.00

36

No


RAD23A

0.22

0.09

13

No


ABCC6

2.88E-10

0.36

59

Yes


CHAC1

0.035

0.12

12

No


FLJ11151

8.62E-7

0.43

181

No


BACE1

0.0037

0.17

79

No


Yes

THNSL2

<1E-16

0.95

74

No


PKDREJ

0.023

0.02

24

Yes


KLRD1

0.084

0.01

61

No


KIAA1618

0.088

0.09

63

Yes


C19orf62

0.022

0.01

41

Yes


MYL2

0.061

0.00

52

No


RPL18

0.17

0.10

19

Yes


HLA-C

<1E-16

0.51

153

Yes


COX6C

0.000097

0.15

36

No


COPS7A

0.048

0.04

47

No


PLEKHJ1

0.048

0.14

22

Yes


HSPC157

<1E-16

0.84

64

Yes


HMGCS2

0.0026

0.25

76

Yes


OR8H1

0.049

0.23

49

No


CYR61

0.012

0.11

100

No


ELOF1

0.019

0.04

32

No


ARF1

0.065

0.12

55

Yes


a Highest SNP association shown. All other significant SNPs are listed in Additional file 5. Apparent cis-acting eQTL are identified in bold.

b Copy number variation (CNV) as identified in the UCSC Genome Browser.

Mason et al. BMC Genomics 2011 12:98   doi:10.1186/1471-2164-12-98

Open Data