Table 4

List of differentially regulated genes in key functional groups.

Gene locus in EA 2018

Gene locus in ATCC 824

9 h (Log2Ratio 2018/824)

13 h (Log2Ratio 2018/824)

17 h (Log2Ratio 2018/824)

21 h (Log2Ratio 2018/824)

24 h (Log2Ratio 2018/824)

30 h (Log2Ratio 2018/824)

Product Name


Carbohydrate transportant and metabolism


CEA_G0343

CA_C0332

-2.97436

-3.22501

-2.37758

-2.08064

-2.57556

-1.49158

Beta-mannanase

CEA_G0501

CA_C0490

2.331505

2.410311

2.244172

2.361906

2.703307

2.474026

sugar kinase, N-terminal region - uncharacterized protein

CEA_G0552

CA_C0539

-3.20909

-3.00324

-2.93013

-2.29917

-3.34939

-3.01922

ChW repeat-containing mannanase ManB

CEA_G0553

CA_C0540

-3.097

-3.03398

-2.7227

-2.28306

-3.3665

-2.72934

ChW repeat-containing mannanase ManB

CEA_G1677

CA_C1664

1.744408

2.013214

2.53088

1.134795

1.816259

2.062687

glycogen phosphorylase

CEA_G2012

CA_C1997

3.052977

3.503142

3.004392

2.8712

2.075025

1.372718

glycosyltransferase

CEA_G2022

CA_C2007

3.179932

3.308867

2.812136

2.509044

1.656072

1.958591

glycosyltransferase

CEA_G2528

CA_C2514

2.588809

2.748177

3.625871

4.329215

2.708288

1.042021

Beta galactosidase

CEA_G2815

CA_C2807

2.40568

2.124155

2.476058

2.653992

2.808752

1.737289

endo-1,3(4)-beta-glucanase family protein 16

CEA_G2818

CA_C2810

1.835243

2.287891

2.800041

3.929157

3.739976

4.256289

glucoamylase family protein

CEA_G3051

CA_C3045

-2.41601

-2.05151

-2.19775

-2.37262

-2.3321

-2.16444

PHP family hydrolase

CEA_G3060

CA_C3054

-3.63818

-4.38617

-4.64833

-5.02922

-5.12371

-3.50751

phosphoheptose isomerase

CEA_G3426

CA_C3422

-1.07396

-2.79221

-3.22016

-2.15086

-2.69786

-1.37931

sugar:proton symporter (xylulose)

CEA_P0052

CA_P0053

2.477697

2.868013

3.649329

3.695172

3.721454

5.987476

xylanase

CEA_P0053

CA_P0054

4.25084

2.735168

2.447001

3.424303

3.598697

5.185082

xylanase/chitin deacetylase family protein

CEA_P0065

CA_P0066

3.062167

1.145145

2.159875

4.902259

3.81378

2.953822

mannose-specific phosphotransferase system component IIAB

CEA_P0066

CA_P0067

2.925021

1.579742

2.174524

4.883877

3.683632

2.826095

mannose/fructose-specific phosphotransferase system component IIC

CEA_P0067

CA_P0068

3.006142

1.74298

2.611356

4.717371

3.502957

2.456002

mannose-specific phosphotransferase system component IID

CEA_P0115

CA_P0116

1.777221

2.342324

2.902238

3.126694

3.321994

5.378643

xylanase


Amino acid transport and metabolism


CEA_G0180

CA_C0176

2.56498

2.063235

2.36635

2.08086

3.251555

3.705152

oligopeptide-binding protein, periplasmic component

CEA_G0327

CA_C0316

-4.09229

6.429377

7.957548

6.881528

4.185199

2.037144

ornithine carbomoyltransferase

CEA_G0390

CA_C0380

-4.23921

5.06975

5.365591

5.142555

3.394778

2.099342

periplasmic amino acid-binding protein

CEA_G0984

CA_C0973

-4.67305

6.390879

8.78089

7.141168

3.889621

2.522783

argininosuccinate synthase

CEA_G0985

CA_C0974

-4.03279

6.033303

8.738086

7.66813

4.662246

3.462605

argininosuccinate lyase

CEA_G2392

CA_C2377

-4.81354

-4.50847

-4.89131

-5.25303

-5.6598

-6.94396

oligopeptide ABC-type transporter, periplasmic binding component (frameshift)

CEA_G2403

CA_C2388

-3.653

6.58659

9.490741

7.214547

3.839977

1.277684

acetylornithine aminotransferase

CEA_G2405

CA_C2390

-4.029

7.044851

9.332151

8.593887

5.225523

1.729156

N-acetyl-gamma-glutamyl-phosphate reductase

CEA_G2406

CA_C2391

-3.63924

6.659273

9.430206

8.041522

4.889782

1.658329

bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein

CEA_G2531

CA_C2517

2.601974

2.875402

3.244092

4.199853

5.407919

5.659197

extracellular neutral metalloprotease, NPRE

CEA_G3059

CA_C3053

-3.80847

-4.46351

-4.85998

-5.20027

-5.64176

-4.16398

histidinol phosphatase related enzyme

CEA_G3625

CA_C3618

-2.33371

4.975742

4.579403

4.356899

3.79613

1.400104

ABC-type polar amino acid transport system, ATPase component

CEA_G3626

CA_C3619

-2.49499

4.94909

4.797836

4.831871

4.227636

1.349231

amino acid ABC transporter permease

CEA_G3627

CA_C3620

-2.79225

4.869307

2.77014

4.039679

3.923914

1.658129

amino acid ABC transporter periplasmic-binding protein

CEA_G3629

CA_C3622

3.744723

1.616914

-1.60643

-2.30924

-3.70552

-4.20925

benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase

CEA_G3648

CA_C3641

3.877563

5.273677

6.532841

7.05381

6.150331

2.645978

oligopeptide ABC transporter, ATPase component

CEA_G3649

CA_C3642

3.862767

5.064748

6.213521

7.100308

6.123778

2.328286

oligopeptide ABC transporter, ATPase component

CEA_G3651

CA_C3644

3.540737

4.731217

4.796332

6.751584

6.151055

3.301733

oligopeptide ABC transporter, permease component


Lipid transport and metabolism


CEA_P0077

CA_P0078

-1.03663

-2.39938

-2.90422

-5.61457

-6.37659

-6.669

acetyl-CoA acetyltransferase

CEA_G0500

CA_C0489

2.843362

2.727643

3.104514

2.258672

2.789674

2.994569

4'-phosphopantetheinyl transferase

CEA_G2024

CA_C2009

3.02793

3.412819

2.753976

2.880761

2.465438

1.317947

3-hydroxyacyl-CoA dehydrogenase

CEA_G2027

CA_C2012

3.139119

3.519089

2.760385

2.466674

1.747722

1.295802

enoyl-CoA hydratase

CEA_G2023

CA_C2008

3.21547

3.393795

2.65468

2.624962

1.849978

1.696553

3-oxoacyl-(acyl-carrier-protein) synthase

CEA_G0825

CA_C0814

3.447389

2.690101

3.341654

3.492821

2.738719

2.617536

3-oxoacyl-

CEA_G3630

CA_C3623

3.78405

1.698615

-1.62094

-2.13197

-3.66189

-4.47732

2-hydroxyglutaryl-CoA dehydratase activator


Coenzyme transport and metabolism


CEA_G2539

CA_C2526

-5.80423

-4.29934

-2.18936

-3.20732

-2.04208

-2.09088

6-pyruvoyl-tetrahydropterin synthase related protein

CEA_G0110

CA_C0109

-1.93293

-1.10289

-4.51818

-4.22606

-3.40598

-5.95312

sulfate adenylyltransferase subunit 2

CEA_G2240

CA_C2226

1.175604

1.630568

1.933437

3.44313

4.132037

3.011011

branched-chain amino acid aminotransferase

CEA_G2817

CA_C2809

1.909506

2.362089

1.59545

3.297164

2.183049

1.029092

HD superfamily hydrolase

CEA_G2037

CA_C2022

2.45013

1.945668

2.521958

2.427533

2.187431

3.238565

molybdopterin biosynthesis protein MoaB

CEA_G3633

CA_C3626

2.627562

1.339719

-1.38437

-2.32524

-3.57634

-5.06491

GTP cyclohydrolase I

CEA_G2036

CA_C2021

2.849463

2.144804

2.666979

4.297463

3.319713

3.863173

molybdopterin biosynthesis protein MoeA

CEA_G2009

CA_C1994

3.136184

3.75827

3.408469

2.84809

1.881193

1.268359

molybdopterin biosynthesis protein MoaB

CEA_G2035

CA_C2020

3.146626

3.515592

5.182665

4.677354

4.692789

4.012931

molybdopterin biosynthesis protein MoeA

CEA_G3631

CA_C3624

3.416604

1.490697

-1.38827

-2.23319

-3.83641

-6.15768

6-pyruvoyl-tetrahydropterin synthase


Signal transduction


CEA_G0078

CA_C0078

-4.99228

-8.71284

-9.43594

-9.21854

-9.14927

-7.97564

putative accessory gene regulator protein

CEA_G3328

CA_C3325

-1.00804

-2.85267

-4.3502

-5.19446

-4.39209

-5.05262

periplasmic amino acid binding protein

CEA_G0921

CA_C0909

-2.84748

-1.88833

-1.93256

-1.50557

-2.64087

-2.89144

methyl-accepting chemotaxis protein

CEA_G2085

CA_C2071

2.455498

2.263411

2.413649

1.803983

2.20351

2.550339

Spo0A protein

CEA_G2422

CA_C2407

3.784844

1.475039

1.927948

1.823945

2.526403

2.502499

CheY-like domain-containing protein

CEA_G0448

CA_C0437

2.192653

1.378372

2.665966

1.827148

2.252286

2.342264

sensory transduction histidine kinase

CEA_G3025

CA_C3019

-2.65448

3.491201

3.449102

2.735229

1.336433

1.266833

sensory transduction protein

CEA_G0296

CA_C0289

1.792323

1.978035

2.438903

2.751395

3.435751

3.052853

response regulator

CEA_G2782

CA_C2774

1.625932

1.895382

3.060796

2.846554

2.092881

1.726376

methyl-accepting chemotaxis protein

CEA_G0334

CA_C0323

3.362504

2.662176

2.652177

3.222052

4.952742

2.037345

sensory transduction histidine kinase

CEA_G3627

CA_C3620

-2.79225

4.869307

2.77014

4.039679

3.923914

1.658129

amino acid ABC transporter periplasmic-binding protein

CEA_G0390

CA_C0380

-4.23921

5.06975

5.365591

5.142555

3.394778

2.099342

periplasmic amino acid-binding protein


Energy production and convertion


CEA_G1083

CA_C1072

3.271648

3.230747

4.254617

2.59071

2.723209

3.766376

Fe-S oxidoreductase

CEA_G2012

CA_C1997

3.052977

3.503142

3.004392

2.8712

2.075025

1.372718

glycosyltransferase

CEA_G2015

CA_C2000

2.963078

3.638083

2.745804

2.983214

2.587284

2.204476

indolepyruvate oxidoreductase subunit beta

CEA_G2016

CA_C2001

2.832561

3.688549

3.007107

3.355002

2.718563

2.206461

indolepyruvate ferredoxin oxidoreductase, subunit

CEA_G2022

CA_C2007

3.179932

3.308867

2.812136

2.509044

1.656072

1.958591

glycosyltransferase

CEA_G2025

CA_C2010

3.282342

3.533526

2.84142

3.003615

2.50221

2.005231

Fe-S oxidoreductase

CEA_G2555

CA_C2542

8.22595

5.876659

5.423124

5.135223

4.224852

4.280766

FAD/FMN-containing dehydrogenase

CEA_G2556

CA_C2543

8.451735

6.100494

5.401602

5.24343

4.426238

3.987954

electron-transferring flavoprotein large subunit

CEA_G2557

CA_C2544

7.904188

6.040402

4.848558

4.578106

4.214698

3.969443

electron-transferring flavoprotein small subunit

CEA_G3411

CA_C3408

-2.71993

-3.64684

-4.53359

-4.7967

-4.89809

-4.45863

NADH oxidase


Cell mobility


CEA_G0921

CA_C0909

-2.84748

-1.88833

-1.93256

-1.50557

-2.64087

-2.89144

methyl-accepting chemotaxis protein

CEA_G3572

CA_C3565

1.783589

1.966743

1.626123

1.303128

1.522492

1.56009

cell adhesion domain-containing protein

CEA_G3091

CA_C3085

1.669031

1.879947

1.641572

3.329325

2.811493

2.558158

TPR repeat-containing cell adhesion protein

CEA_G3092

CA_C3086

1.689695

1.7646

1.823344

3.167841

2.629106

2.423856

cell adhesion domain-containing protein

CEA_G2782

CA_C2774

1.625932

1.895382

3.060796

2.846554

2.092881

1.726376

methyl-accepting chemotaxis protein

CEA_P0159

CA_P0160

2.878477

3.739495

3.515178

3.50976

3.19802

3.547315

cell-adhesion domain-containing protein


Hu et al. BMC Genomics 2011 12:93   doi:10.1186/1471-2164-12-93

Open Data