Table 2

EA 2018 gene variations associated with key phenotypes

Gene locus in EA 2018

Gene locus in ATCC 824

Gene variation sites in EA 2018

Gene variation sites in ATCC 824

Protein variation sites in EA 2018

Protein variation sites in ATCC 824

Product name


Solvent formation related genes


CEA_G1048

CAC1036

899(T)

899(C)

300(V)

300(A)

Pyruvate kinase

CEA_G1755

CAC1742

391(A)

391(G)

131(N)

131(D)

phosphotransacetylase

CEA_G2463

CAC2449

256(A)

256(G)

86(S)

86(G)

Predicted flavoprotein

CEA_G2485

CAC2471

439(A)

438-439(-)

147-150(R,L,P,I)

147-150 (G,C,L,Stop codon)

Transcriptional regulator, TetR/AcrR family

CEA_G2556

CAC2543

241-249 (G,T,A,G, A,T,C,A,T)

240-241(---)

81-83(V,D,H)

80-81(---)

Electron-transferring flavoprotein large subunit

CEA_G2806

CAC2798

286(A)

286(G)

96(M)

96(V)

NADH:flavin oxidoreductase

CEA_P0058

CA_P0059

754(A)

754(C)

252(N)

252(H)

Alcohol dehydrogenase

CEA_P0077

CA_P0078

91(A)

91(G)

31(T)

31(A)

acetyl-CoA acetyltransferase

CEA_P0140

CA_P0141

566(T)

566(C)

189(I)

189(T)

Periplasmic hydrogenase small subunit, dehydrogenase


Substrate utilization related genes


CEA_G0239

CAC0234

1072(T)

1072(C)

358(Stop codon)

358(Q)

PTS system, fructoso-specific IIBC component

CEA_G1333

CAC1319

5(T)

5(C)

2(I)

2(T)

Glycerol uptake facilitator protein, GLPF

CEA_G1472

CAC1456

974(T)

974(A)

325(M)

325(K)

Sugar-binding periplasmic protein

CEA_G2622

CAC2613

270(T)

270(G)

90(C)

90(W)

Transcriptional regulators of NagC/XylR family

CEA_G2919

CAC2912

97(A)

97(C)

33(T)

33(P)

Sugar-binding periplasmic protein

CEA_P0052

CA_P0053

317(C)

317(T)

106(P)

106(L)

Xylanase, glycosyl hydrolase family 10


Sporulation related genes


CEA_G0080

CAC0080

1160(A)

1159-1160(-)

387-392(N,I,Q,D,L,Stop codon)

387-391(I,Y,K,I,Y,K)

Histidine kinase-like ATPase

CEA_G0656

CAC0644

1226(T)

1226(G)

409(V)

409(G)

Spore germination protein gerKA

CEA_G0710

CAC0699

416(C)

416(T)

139(T)

139(I)

Spore photoproduct lyase, splB

CEA_G2066

CAC2052

688(A)

687-688(-)

230-248 (18 amino acid)

230-238 (7 amino acid and a Stop Codon)

DNA-dependent RNA polymerase sigma subunit

CEA_G3736

CAC3729

374(T)

374(C)

125(L)

125(P)

Stage 0 sporulation J, ParB family of DNA-binding proteins

CEA_P0016

CA_P0017

11,245(G,A)

11,245(T,C)

4,82(E,G)

4,82(A,V)

Spore germination protein, GRKB

CEA_P0019

CA_P0020

1120(C)

1120(T)

407(A)

407(V)

Spore germination protein, GRKA

CEA_P0021

CA_P0022

-151(T)

104(C)

1(---)

1-85(85 amino acids insertion)

Spore germination protein, GRKB


Numbers in gene or protein variation sites lines indicated the variation sites in genes; the letters in bracket means the corresponding variation bases or amino acid; the symbol "-" means deletion in genes; the symbol "---" means consecutive deletion in genes; "No" means no amino acid variation; "Stop codon" means this site is mutated to stop codon.

Hu et al. BMC Genomics 2011 12:93   doi:10.1186/1471-2164-12-93

Open Data