Genetic and epigenetic variations contributed by Alu retrotransposition
1 Falk Brain Tumor Center, Cancer Biology and Epigenomics Program, Children's Memorial Research Center, Chicago IL 60614-3394, USA
2 Department of Pediatrics; Feinberg School of Medicine, Northwestern University, Chicago IL 60614-3394, USA
BMC Genomics 2011, 12:617 doi:10.1186/1471-2164-12-617Published: 20 December 2011
Additional file 1:
Table S1. Putatively recent Alu insertions. Alu insertions identified in eight Alu bisulfite PCR libraries.
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Additional file 2:
Table S2. Clusters of putative Alu insertions. Alu insertions and their gene annotation.
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Additional file 3:
Figure S1. Methylation pattern of recent Alu insertions. To determine the methylation status, the sequences corresponding to the first half of Alu elements plus its 5' flanking regions [31,32] were aligned to the Alu element sequences generated in this study. NC1: Normal cerebellum and NC2: normal 4th ventricle lining tissue; PA1, PA2, PA3, PA4, and PA5: primary ependymoma tumor; RL: ependymoma tumor relapsed from PA3.
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Additional file 4:
Table S3. Alu methylation level. Methylation levels of mapped and 19 non-mapped Alu elements.
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