Table 3 |
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Top-ranking canonical pathways identified using IPA |
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|
Canonical Pathway Name |
P-value |
Ratio |
|
|
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|
Natural killer cell signalling |
3.06 × 10-4 |
23/112 (0.205) |
|
|
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|
Communication between innate and adaptive immune cells |
4.11 × 10-4 |
17/89 (0.191) |
|
|
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|
TREM1 signalling |
2.20 × 10-3 |
15/69 (0.217) |
|
|
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|
Dendritic cell maturation |
4.96 × 10-3 |
29/174 (0.167) |
|
|
||
|
Cysteine metabolism |
7.43 × 10-3 |
9/90 (0.100) |
|
|
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|
JAK/STAT signalling |
8.22 × 10-3 |
15/64 (0.234) |
|
|
||
|
NRF2-mediated oxidative stress response |
8.98 × 10-3 |
35/183 (0.191) |
|
|
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|
T cell receptor signalling |
1.08 × 10-2 |
20/107 (0.187) |
|
|
||
|
IL6 signalling |
1.52 × 10-2 |
20/93 (0.215) |
|
|
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|
CCR5 signalling in macrophages |
1.84 × 10-2 |
16/92 (0.174) |
|
|
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|
Chemokine signalling |
1.92 × 10-2 |
15/75 (0.200) |
|
|
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|
Calcium-induced T-lymphocyte apoptosis |
2.07 × 10-2 |
12/66 (0.182) |
|
|
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|
IL-17 signalling |
2.21 × 10-2 |
16/74 (0.216) |
|
|
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|
Prolactin signalling |
2.21 × 10-2 |
16/75 (0.213) |
|
|
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|
Synaptic long term potentiation |
2.22 × 10-2 |
19/113 (0.168) |
|
|
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|
Toll-like receptor signalling |
2.63 × 10-2 |
11/54 (0.204) |
|
|
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|
FLT3 signalling in hematopoietic progenitor cells |
2.77 × 10-2 |
15/74 (0.203) |
|
|
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|
Systemic lupus erythematosus signalling |
2.81 × 10-2 |
20/151 (0.132) |
|
|
||
|
Renin angiotensin signalling |
3.01 × 10-2 |
21/120 (0.175) |
|
|
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|
Phospholipase C signalling |
3.28 × 10-2 |
39/253 (0.154) |
|
|
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|
Oncostatin M signalling |
3.36 × 10-2 |
9/35 (0.257) |
|
|
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|
Thyroid cancer signalling |
3.36 × 10-2 |
9/42 (0.214) |
|
|
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|
B cell receptor signalling |
3.72 × 10-2 |
25/154 (0.162) |
|
|
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|
Interferon signalling |
3.97 × 10-2 |
6/30 (0.200) |
|
|
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|
Production of nitric oxide and reactive oxygen species in macrophages |
4.13 × 10-2 |
28/185 (0.151) |
|
|
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|
NF-κB signalling |
4.17 × 10-2 |
25/152 (0.164) |
|
|
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|
Notch signalling |
4.29 × 10-2 |
8/43 (0.186) |
|
|
||
|
IL10 signalling |
4.36 × 10-2 |
13/70 (0.186) |
|
|
||
|
P38 MAPK signalling |
4.57 × 10-2 |
17/97 (0.175) |
|
|
||
|
Role of NFAT in regulation of the immune response |
4.70 × 10-2 |
29/196 (0.148) |
|
|
||
|
Parkinson's signalling |
5.00 × 10-2 |
5/17 (0.294) |
|
|
||
|
The top ranking canonical pathways identified by IPA are listed according to P-values. The ratio indicates the number of differentially expressed genes involved in each canonical pathway divided by the total number of genes within each pathway as per the IPA Knowledge Base. |
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|
Killick et al. BMC Genomics 2011 12:611 doi:10.1186/1471-2164-12-611 |
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