Table 3

Top-ranking canonical pathways identified using IPA

Canonical Pathway Name

P-value

Ratio


Natural killer cell signalling

3.06 × 10-4

23/112 (0.205)


Communication between innate and adaptive immune cells

4.11 × 10-4

17/89 (0.191)


TREM1 signalling

2.20 × 10-3

15/69 (0.217)


Dendritic cell maturation

4.96 × 10-3

29/174 (0.167)


Cysteine metabolism

7.43 × 10-3

9/90 (0.100)


JAK/STAT signalling

8.22 × 10-3

15/64 (0.234)


NRF2-mediated oxidative stress response

8.98 × 10-3

35/183 (0.191)


T cell receptor signalling

1.08 × 10-2

20/107 (0.187)


IL6 signalling

1.52 × 10-2

20/93 (0.215)


CCR5 signalling in macrophages

1.84 × 10-2

16/92 (0.174)


Chemokine signalling

1.92 × 10-2

15/75 (0.200)


Calcium-induced T-lymphocyte apoptosis

2.07 × 10-2

12/66 (0.182)


IL-17 signalling

2.21 × 10-2

16/74 (0.216)


Prolactin signalling

2.21 × 10-2

16/75 (0.213)


Synaptic long term potentiation

2.22 × 10-2

19/113 (0.168)


Toll-like receptor signalling

2.63 × 10-2

11/54 (0.204)


FLT3 signalling in hematopoietic progenitor cells

2.77 × 10-2

15/74 (0.203)


Systemic lupus erythematosus signalling

2.81 × 10-2

20/151 (0.132)


Renin angiotensin signalling

3.01 × 10-2

21/120 (0.175)


Phospholipase C signalling

3.28 × 10-2

39/253 (0.154)


Oncostatin M signalling

3.36 × 10-2

9/35 (0.257)


Thyroid cancer signalling

3.36 × 10-2

9/42 (0.214)


B cell receptor signalling

3.72 × 10-2

25/154 (0.162)


Interferon signalling

3.97 × 10-2

6/30 (0.200)


Production of nitric oxide and reactive oxygen species in macrophages

4.13 × 10-2

28/185 (0.151)


NF-κB signalling

4.17 × 10-2

25/152 (0.164)


Notch signalling

4.29 × 10-2

8/43 (0.186)


IL10 signalling

4.36 × 10-2

13/70 (0.186)


P38 MAPK signalling

4.57 × 10-2

17/97 (0.175)


Role of NFAT in regulation of the immune response

4.70 × 10-2

29/196 (0.148)


Parkinson's signalling

5.00 × 10-2

5/17 (0.294)


The top ranking canonical pathways identified by IPA are listed according to P-values. The ratio indicates the number of differentially expressed genes involved in each canonical pathway divided by the total number of genes within each pathway as per the IPA Knowledge Base.

Killick et al. BMC Genomics 2011 12:611   doi:10.1186/1471-2164-12-611

Open Data