Additional file 3.

Enriched motifs present in the promoters of genes in the identified WGCNA and differentially connected modules. Genes present in each of the identified WGCNA and differentially connected modules were examined by using GSEA for enrichment of conserved cis-acting regulatory motifs [19]. The database within GSEA included gene-associated anonymous motifs conserved in the human, mouse, rat and dog genomes and conserved gene-associated transcription factor binding sites. The motifs were restricted to a 'promoter' sequence window corresponding to ± 2 kb of the transcription start site. P-values ≤ 0.05 were considered significant.

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Kogelman et al. BMC Genomics 2011 12:607   doi:10.1186/1471-2164-12-607