Table 1

Top 21 Gene Ontology categories between the YH and the mDC samples

Gene name

GO ID

NM

GO category

Methylation level of mDC

Methylation level of YH

P value


HELLS

GO:0005524

NM_018063

ATP binding

33.333

1.316

4.54E-03

MSI1

GO:0007399

NM_002442

nervous system development

20.833

2.632

8.23E-03

CEBPE

GO:0046983

NM_001805

protein dimerization activity

23.739

9.081

5.58E-79

EML2

GO:0007605

NM_012155

sensory perception of sound

27.621

13.554

9.63E-12

GLTSCR2

GO:0005634

NM_015710

nuclear

23.36

11.579

1.52E-04

TBC1D17

GO:0005096

NM_024682

GTPase activator activity

25.197

3.425

3.51E-14

BDH1

GO:0016491

NM_203314

oxidoreductase activity

22.892

11.345

6.49E-13

COL23A1

GO:0016021

NM_173465

integral to membrane

20.896

10.081

5.73E-03

WASF1

GO:0030041

NM_001024936

actin filament polymerization

22.215

10.467

9.32E-23

MYO1G

GO:0016459

NM_033054

myosin complex

21.907

8.239

5.16E-13

ARMCX2

GO:0016021

NM_014782

integral to membrane

31.395

14.286

5.12E-04

MMP21

GO:0008270

NM_147191

zinc ion binding

9.375

33.862

1.05E-07

ITGA7

GO:0016020

NM_002206

membrane

10.879

21.88

1.39E-11

DHRS12

GO:0016491

NM_024705

oxidoreductase activity

8.696

23.144

1.55E-05

AURKC

GO:0016740

NM_001015878

transferase activity

10.256

30.769

9.17E-03

SOX18

GO:0006357

NM_018419

regulation of transcription from RNA polymerase II promoter

3.656

20.225

2.55E-15

CIDEC

GO:0006917

NM_022094

induction of apoptosis

8.333

20.098

6.22E-04

PF4

GO:0045653

NM_002619

negative regulation of megakaryocyte differentiation

0

22.222

3.13E-03

MARCKS

GO:0051015

NM_002356

actin filament binding

5.405

30.088

4.66E-03

PRAF2

GO:0016021

NM_007213

integral to membrane

8.333

26.02

3.00E-03

FAM155B

GO:0016021

NM_015686

integral to membrane

0

21.053

4.02E-04


The methylation level represents the average methylation level of the CpGs in the region. The P value was calculated using the chi-square test.

Wang et al. BMC Genomics 2011 12:597   doi:10.1186/1471-2164-12-597

Open Data