Additional file 2.

CTCF binding demarcates estrogen-regulated genes. CTCF and ER binding profiles were mapped by ChIP-sequencing in MCF-7 cells. Examples of three classic estrogen-regulated genes, where ER binding events that regulate expression of the genes are flanked by CTCF binding events, are shown. A. The XBP1 genomic locus. B. The NRIP1 genomic locus. C. The GREB1 genomic locus.

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Ross-Innes et al. BMC Genomics 2011 12:593   doi:10.1186/1471-2164-12-593