Cell-line unique CTCF binding events are more likely to overlap with cell-line specific ER binding events. ER binding was mapped in MCF-7 and ZR75-1 cells using ChIP-seq. Heatmap showing MCF-7- and ZR75-1-unique ER binding events. The window represents -/+ 5 kb regions from the centre of the ER binding events. Shared ER binding events, as well as MCF-7 and ZR75-1 unique ER binding events were overlapped with CTCF binding events that were unique to MCF-7, ZR75-1 or MCF10A cells as well as CTCF binding events that were shared between all three cell lines (Common CTCF). Percentage overlaps are shown.
Ross-Innes et al. BMC Genomics 2011 12:593 doi:10.1186/1471-2164-12-593