Table 1

Exosome components in the parasitic protists

Core and peripheral eukaryotic exosome components


S. cerevisae

H. sapiens

A. thaliana

T. brucei (TREU)

P. falciparum

T. vaginalis

E. histolyica

(HM-1_IMSS)

G. lamblia (WB)

Canonical Archaeal exosome


Ring Components

rrp41

YGR195W

*NP_061910

*AT3G61620

Tb927.10.7450

*NP_342241

rrp42

YDL111C

NP_055819

Tb927.1.2580

NP_342240

rrp43

YCR035C

NP_852480

Tb11.01.8320

**

rrp45

YDR280W

NP_001029366 NP_005024

AT4G27490 AT3G46210 AT3G07750 AT3G12990 AT3G60500 AT1G60080

Tb927.6.670

PF14_0256 PFB0415c MAL13P1.204 PF13_0340

TVAG_250040 TVAG_441560 TVAG_287740 TVAG_027130 TVAG_453750 TVAG_189430 TVAG_220800

EHI_040320 EHI_166910 EHI_126330 EHI_086520 EHI_188080 EHI_000580

GL50803_ 1890 GL50803_5632 GL50803_40007 GL50803_ 9847

**

rrp46

YGR095C

NP_064543.3

Tb927.2.2180

**

mtr3

YGR158C

NP_478126

Tb11.01.2820

**


Stabilizers

rrp4

YHR069C

NP_055100

*AT1G03360

*Tb927.7.4670

PFD0515w

TVAG_246740

EHI_163510

GL50803_33022

NP_342242

rrp40

YOL142W

NP_057126

AT2G25355 AT4G32175

Tb09.160.5160

MAL13P1.36

TVAG_380110

EHI_004770

GL50803_17091

**

csl4

YNL232W

NP_057130

AT5G38890

Tb927.5.1200

MAL7P1.104

TVAG_110240 TVAG_121320

U

U

NP_341842


Peripheral

rrp6

*YOR001W

*NP_001001998 NP_002676

AT5G35910

AT2G32415

AT1G54440

Tb927.4.1630

MAL13P1.311 PF14_0473

TVAG_053630 TVAG_197890 TVAG_283650

EHI_021400 EHI_064630

U

**

rrp44

*YOL021C

NP_001121698 NP_055768

AT2G17510

AT1G77680

AT5G02250

Tb11.02.5380 Tb11.01.0260

MAL13P1.289

TVAG_311220

EHI_160720

GL50803_112718

**


The chart displays a selection of organisms and the components of their exosomes divided into the ring, stabilizing and peripheral components. Representative metazoan eukaryotes, S. cerevisiae, H. sapiens, and A. thaliana, are identified on the left most side of the chart, while several species of single-celled eukaryotic parasites are listed in the middle and right side of the chart. The far right column displays the typical proteins composing an archaeal exosome. Components of the exosome whose activity has been confirmed experimentally are marked with asterisks. Gene annotations are from Saccharmoyces Genome Database (S. cerevisiae), National Center for Biotechnology Information (H. sapiens sapiens and canonical archaeal exosome S. solfataricus), The Arabidopsis Information Resource (A. thaliana), and Eukaryotic Pathogen Database (T. brucei, P. falciparum, T. vaginalis, E. histolytica, and G. lamblia). Boxes are coded as follows; normal font/identified, bold font/unable to identify the exact identity, **/non-existant, and U/not identified.

Williams and Elmendorf BMC Genomics 2011 12:586   doi:10.1186/1471-2164-12-586

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