Cis and trans human ceQTLs. (A) Trans ceQTL. RPL18P4 on chromosome 7 displays an increase in log10(RH/A23) gene expression as log10(RH/A23) copy number of a marker at 53.7 Mb on chromosome 19 increases (α = 5.2, -log10 P = 8.35). (B) Example of negative α trans ceQTL. Log10(RH/A23) gene expression of DPH3 on chromosome 3 decreases as log10(RH/A23) copy number of a marker at 128.1 Mb on chromosome 12 increases (α = -0.72, -log10 P = 4.27). (C) Cis ceQTL for GNB1 is located at 1.7 Mb on the beginning portion of chromosome 1. Red line denotes position of regulated gene. (D) Multiple trans ceQTLs on Chromosome 11 regulating RPS13 on chromosome 1. The peaks located at 17.1 Mb and 47 Mb show strongest evidence of regulation. Points are aCGH markers plotted along chromosomes. Centromeres are grey.
Wang et al. BMC Genomics 2011 12:562 doi:10.1186/1471-2164-12-562