Research article
Recent human evolution has shaped geographical differences in susceptibility to disease
1 Institute of Evolutionary Biology (UPF-CSIC), PRBB, Doctor Aiguader 88, 08003, Barcelona, Catalonia, Spain
2 Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
3 CIBER en Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain
4 National Institute for Bioinformatics, Universitat Pompeu Fabra, Barcelona, Spain
5 CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade de Porto, Campus Agrário de Vairão, 4485 - 661, Vairão, Portugal
6 Pharmacogenomics and Comparative Genomics Unit, Centro de Investigación Príncipe Felipe (CIPF), Valencia 46012, Spain
7 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain
BMC Genomics 2011, 12:55 doi:10.1186/1471-2164-12-55
Published: 24 January 2011Additional files
Additional file 1:
Text summary of the steps and filters to ascertain the Global and Continental Sets.
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Additional file 2:
Main Features and Population Differentiation values in the selected 890 associations from the Global Set.
Format: XLS Size: 230KB Download file
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Additional file 3:
Main Features and Population Differentiation values in the selected 37 associations from the Continental Set.
Format: XLS Size: 41KB Download file
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Additional file 4:
Summary of Spearman's (ρ) correlation coefficients between the world-wide replicability (in %) and the average genic population differentiation (FST) for the 890 associations from the Global Set.
Format: XLS Size: 32KB Download file
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Additional file 5:
Summary of Spearman's (ρ) correlation coefficients between the world-wide replicability (in %) and the average population differentiation (FST) for the 50,317 SNPs from the Global Set. Each SNP has been assigned the replicability of the gene they locate.
Format: XLS Size: 28KB Download file
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Additional file 6:
Summary of Spearman's (ρ) correlation coefficients between the world-wide replicability (in %) and the average FST for tagSNPs from the 890 associations from the Global Set. Each tagSNP has been assigned the replicability of the gene they locate
Format: XLS Size: 28KB Download file
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Additional file 7:
Main Features from the 564 studies of the 37 associations from the Continental Set.
Format: XLS Size: 119KB Download file
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Additional file 8:
Main Features and Population Differentiation values in the 54 SNP markers from the selected 37 associations from the Continental Set.
Format: XLS Size: 40KB Download file
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Additional file 9:
Main Features and summary of population-specific ancestrality status for the 890 associations from the Global Set.
Format: XLS Size: 244KB Download file
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Additional file 10:
Gene enrichment analysis for the PANTHER database "Biological Process" categories for the 403 genes from the 890 associations of the Global Set.
Format: XLS Size: 59KB Download file
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