Open Access Highly Accessed Research article

Recent human evolution has shaped geographical differences in susceptibility to disease

Urko M Marigorta1, Oscar Lao2, Ferran Casals1, Francesc Calafell13, Carlos Morcillo-Suárez14, Rui Faria15, Elena Bosch13, François Serra6, Jaume Bertranpetit13, Hernán Dopazo6 and Arcadi Navarro147*

Author Affiliations

1 Institute of Evolutionary Biology (UPF-CSIC), PRBB, Doctor Aiguader 88, 08003, Barcelona, Catalonia, Spain

2 Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands

3 CIBER en Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain

4 National Institute for Bioinformatics, Universitat Pompeu Fabra, Barcelona, Spain

5 CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade de Porto, Campus Agrário de Vairão, 4485 - 661, Vairão, Portugal

6 Pharmacogenomics and Comparative Genomics Unit, Centro de Investigación Príncipe Felipe (CIPF), Valencia 46012, Spain

7 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain

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BMC Genomics 2011, 12:55  doi:10.1186/1471-2164-12-55

Published: 24 January 2011

Additional files

Additional file 1:

Text summary of the steps and filters to ascertain the Global and Continental Sets.

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Additional file 2:

Main Features and Population Differentiation values in the selected 890 associations from the Global Set.

Format: XLS Size: 230KB Download file

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Additional file 3:

Main Features and Population Differentiation values in the selected 37 associations from the Continental Set.

Format: XLS Size: 41KB Download file

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Additional file 4:

Summary of Spearman's (ρ) correlation coefficients between the world-wide replicability (in %) and the average genic population differentiation (FST) for the 890 associations from the Global Set.

Format: XLS Size: 32KB Download file

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Additional file 5:

Summary of Spearman's (ρ) correlation coefficients between the world-wide replicability (in %) and the average population differentiation (FST) for the 50,317 SNPs from the Global Set. Each SNP has been assigned the replicability of the gene they locate.

Format: XLS Size: 28KB Download file

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Additional file 6:

Summary of Spearman's (ρ) correlation coefficients between the world-wide replicability (in %) and the average FST for tagSNPs from the 890 associations from the Global Set. Each tagSNP has been assigned the replicability of the gene they locate

Format: XLS Size: 28KB Download file

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Additional file 7:

Main Features from the 564 studies of the 37 associations from the Continental Set.

Format: XLS Size: 119KB Download file

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Additional file 8:

Main Features and Population Differentiation values in the 54 SNP markers from the selected 37 associations from the Continental Set.

Format: XLS Size: 40KB Download file

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Additional file 9:

Main Features and summary of population-specific ancestrality status for the 890 associations from the Global Set.

Format: XLS Size: 244KB Download file

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Additional file 10:

Gene enrichment analysis for the PANTHER database "Biological Process" categories for the 403 genes from the 890 associations of the Global Set.

Format: XLS Size: 59KB Download file

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