Table 2

Top Canonical Pathways from IPA for probes showing differential methylation across gestation

First v Second trimester

p-value

# differentially methylated genes/# genes in the pathway


Communication between Innate and Adaptive Immune Cells

6.39E-05

6/109


Role of Cytokines in Mediating Communication between Immune Cells

1.53E-03

4/56


Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

6E-03

4/92


Calcium Signaling

6.81E-03

6/204


Crosstalk between Dendritic Cells and Natural Killer Cells

1.04E-02

4/97


Second v Third trimester

p-value

# differentially methylated genes/# genes in the pathway


Systemic Lupus Erythematosus Signaling

4.72E-03

5/166


Crosstalk between Dendritic Cells and Natural Killer Cells

8.2E-03

4/97


Role of NFAT in Regulation of the Immune Response

2.05E-02

5/199


Agrin Interactions at Neuromuscular Junction

2.35E-02

3/69


Wnt/β-catenin Signaling

2.51E-02

5/172


First v Third trimester

p-value

# differentially methylated genes/# genes in the pathway


Communication between Innate and Adaptive Immune Cells

1.69E-07

17/109


Systemic Lupus Erythematosus Signaling

1.9E-06

21/166


Role of Cytokines in Mediating Communication between Immune Cells

1.43E-05

12/56


Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

1.79E-04

13/92


Crosstalk between Dendritic Cells and Natural Killer Cells

2.61E-04

14/97


Novakovic et al. BMC Genomics 2011 12:529   doi:10.1186/1471-2164-12-529

Open Data