Additional file 10.
Relationship between probe methylation level and variation. Relationship between methylation level and inter-individual variation at each gestational age (s2). Probes were separated into three groups: (A) low methylation (β < 0.2), (B) intermediate methylation (0.2 < β > 0.6) and (C) high methylation (β > 0.6). The number of probes was plotted on the y-axis (in log10 scale) and the variance (s2) on the x-axis. Probes with an intermediate methylation level were most likely to show inter-individual variation (B), while probes with a high methylation level were least likely to show inter-individual variation. In fact, most of the probes with a variance of > 0.02 were from the intermediate methylation level (88/106 first trimester, 119/166 second trimester and 255/352 term), even though most of the Infinium probes (63%) are actually in the low methylation group.
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Novakovic et al. BMC Genomics 2011 12:529 doi:10.1186/1471-2164-12-529