Table 2

Summary of chromosome changes in second-generation black and white variants collected in culture and from infected mice.

Starting strain/color

Aberrant chromosome

2nd Generation straina/pigment

Aberrant chromosome(s)


Strains collected in culture

White to black

W2/white

Chr 13

W2-BA/black

Chr 13, 4, 12

W2/white

Chr 13

W2-BB/black

Chr 13, 12b

W3/white

Chr 13

W3-BB/black

Chr 13, 4

W3/white

Chr 13

W3-BC/black

Chr 13, 12

White to white

W2/white

Chr 13

W2-WB/white

Chr 13 (3, 5, 12, 14)b

Black to white

B1/black

none

B1-WA/white

Chr 3b, 11b

B1/black

none

B1-WB/white

Chr 13 (3, 5, 11)b

B1/black

none

B1-WC/white

Chr 13, 5b, 6


Strains collected from mice

White to black

W2/white

Chr 13

W2-MB3/black

Chr 13, 4

W2/white

Chr 13

W2-MB4/black

Chr 13, 4

W2/white

Chr 13

W2-MB5/black

none

W2/white

Chr 13

W2-MB7/black

Chr 13, 4, 12

W2/white

Chr 13

W2-MB8/black

Chr 13, 4

W3/white

Chr 13

W3-MB13/black

Chr 4, 14b

W3/white

Chr 13

W3-MB16/black

none

White to white

W2/white

Chr 13

W2-MW1/white

Chr 13

W2/white

Chr 13

W2-MW2/white

Chr 13

W3/white

Chr 13

W3-MW6/white

Chr 13

Black to white

B6/black

none

B6-MW10/white

none

B6/black

none

B6-MB20/white

none


aThe second generation strains are named after the starting strain followed by the color (B = black and W = white) and a letter or number designation. In the case of strains collected from mice, an M is added before the letter indicating color.

bThese chromosomes show segmental changes. Note that some chromosomes show an elevated copy number but not full disomy perhaps indicating variability among cells in the population.

Hu et al. BMC Genomics 2011 12:526   doi:10.1186/1471-2164-12-526

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