Open Access Research article

Proteomic and biochemical analyses reveal the activation of unfolded protein response, ERK-1/2 and ribosomal protein S6 signaling in experimental autoimmune myocarditis rat model

Joo Hee Chung12, Hee Jung Choi3, Soo Young Kim1, Kwan Soo Hong4, Soo Kee Min5, Myung Hee Nam1, Chan Wha Kim2, Young Ho Koh3* and Jong Bok Seo1*

Author Affiliations

1 Seoul Center, Korea Basic Science Institute, Sungbuk-gu, Seoul 136-713, Republic of Korea

2 BK21 School of Life Sciences & Biotechnology, Korea University, Sungbuk-gu, Seoul 136-701, Republic of Korea

3 ILSONG Institute of Life Science, Hallym University, 1605-4 Gwanyangdong, Anyang, Gyeonggi-do 431-060, Republic of Korea

4 Division of MR Research, Korea Basic Science Institute, Cheongwon 363-883, Republic of Korea

5 Department of Pathology, Hallym Sacred Heart Hospital, Hallym University Medical School, 1605-4 Gwanyangdong, Anyang, Gyeonggi-do 431-060, Republic of Korea

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BMC Genomics 2011, 12:520  doi:10.1186/1471-2164-12-520

Published: 20 October 2011

Additional files

Additional file 1:

Body weight changes in rats with EAM. The mean body weight of EAM rats was compared to that of age-matched control rats. Controls were sacrificed at day 16, and the mean body weight of EAM day 20 rats was compared to that of day 16 control rats.

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Additional file 2:

The reference 2-DE gel image of EAM rat heart tissue. The proteins were separated using IEF (pH 4-7, 18 cm) and 12% SDS-PAGE. Gels were stained with silver nitrate. Blue and red arrows or numbers indicate decreased and increased spots, respectively.

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Additional file 3:

Significantly increased/decreased spots and identified proteins.

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Additional file 4:

Gene ontology analysis results of significantly up-regulated proteins in EAM rat heart tissue.

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Additional file 5:

Gene ontology analysis results of significantly down-regulated proteins in EAM rat heart tissue.

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