Proteomic and biochemical analyses reveal the activation of unfolded protein response, ERK-1/2 and ribosomal protein S6 signaling in experimental autoimmune myocarditis rat model
- Equal contributors
1 Seoul Center, Korea Basic Science Institute, Sungbuk-gu, Seoul 136-713, Republic of Korea
2 BK21 School of Life Sciences & Biotechnology, Korea University, Sungbuk-gu, Seoul 136-701, Republic of Korea
3 ILSONG Institute of Life Science, Hallym University, 1605-4 Gwanyangdong, Anyang, Gyeonggi-do 431-060, Republic of Korea
4 Division of MR Research, Korea Basic Science Institute, Cheongwon 363-883, Republic of Korea
5 Department of Pathology, Hallym Sacred Heart Hospital, Hallym University Medical School, 1605-4 Gwanyangdong, Anyang, Gyeonggi-do 431-060, Republic of Korea
BMC Genomics 2011, 12:520 doi:10.1186/1471-2164-12-520Published: 20 October 2011
Additional file 1:
Body weight changes in rats with EAM. The mean body weight of EAM rats was compared to that of age-matched control rats. Controls were sacrificed at day 16, and the mean body weight of EAM day 20 rats was compared to that of day 16 control rats.
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Additional file 2:
The reference 2-DE gel image of EAM rat heart tissue. The proteins were separated using IEF (pH 4-7, 18 cm) and 12% SDS-PAGE. Gels were stained with silver nitrate. Blue and red arrows or numbers indicate decreased and increased spots, respectively.
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Additional file 3:
Significantly increased/decreased spots and identified proteins.
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Additional file 4:
Gene ontology analysis results of significantly up-regulated proteins in EAM rat heart tissue.
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Additional file 5:
Gene ontology analysis results of significantly down-regulated proteins in EAM rat heart tissue.
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