Open Access Highly Accessed Research article

The human genome: a multifractal analysis

Pedro A Moreno1*, Patricia E Vélez23, Ember Martínez4, Luis E Garreta1, Néstor Díaz4, Siler Amador4, Irene Tischer1, José M Gutiérrez5, Ashwinikumar K Naik6, Fabián Tobar3 and Felipe García3

Author Affiliations

1 Escuela de Ingeniería de Sistemas y Computación, Universidad del Valle, Santiago de Cali, Colombia

2 Profesora del Departamento de Biología, FACNED, Universidad del Cauca, Popayán, Colombia

3 Escuela de Ciencias Básicas. Facultad de Salud, Universidad del Valle, Santiago de Cali, Colombia

4 Departamento de Sistemas, Universidad del Cauca, Popayán, Colombia

5 Instituto de Física de Cantabria, Universidad de Cantabria-CSIC, Santander, España

6 Vaatsalya HealthCare Solutions Pvt Ltd, Bangalore, India

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BMC Genomics 2011, 12:506  doi:10.1186/1471-2164-12-506

Published: 14 October 2011

Additional files

Additional file 1:

Multifractal and molecular parameters for whole human genome. The file contains the Hs_refseq human genome sequence build 36.2 divided by fragments of 300 kb and multifractal and molecular parameters for 9,379 human chromosome fragments. All REs: All repetitive elements.

Format: XLS Size: 9.1MB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 2:

τ(q) parameters for the human genome. The file contains theτ(q) parameters for 9,379 human chromosome fragments.

Format: RAR Size: 179KB Download file

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Additional file 3:

Multivariate analysis per chromosome. The file contains a significant multivariate analysis per chromosome: consolidated components.

Format: XLSX Size: 21KB Download file

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Additional file 4:

Multivariate analysis for all genome. The file contains a significant multivariate analysis for all genome.

Format: XLSX Size: 1.5MB Download file

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Additional file 5:

Determination coefficients per chromosome. The file contains determination coefficients per chromosome between the MD versus several molecular parameters. NCFs: Number of chromosome fragments. NRCF: Number of removed chr. fragments. R2 are indicated as R^2. The seventh column shows the corrected R2 when nine data (sixth column) from the second column are removed from the analyses. (r): for 1 or 2 chromosomic fragments, few Alu content and high multifractality and (0): for 1 chromosomic fragment without Alu content. *: See Figure 3. All REs: All repetitive elements.

Format: XLSX Size: 17KB Download file

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Additional file 6:

VSTRs sequences. The file contains chromosome fragment sequences with VSRTs for chromosomes 21 and Y.

Format: RAR Size: 363KB Download file

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Additional file 7:

The most multifractal chromosome fragments in the human genome. The file contains genomic location of the most multifractal chromosome fragments.

Format: XLSX Size: 656KB Download file

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Additional file 8:

Chromosome fragments with LMM. The file contains a threshold definition and genomic location for the chromosome fragments with LMM.

Format: RAR Size: 637KB Download file

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Additional file 9:

Gene function versus RM. The file contains the analyses by gene functions, KEGGs, KOGs and exons versus RM.

Format: XLS Size: 2.1MB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 10:

Gene family versus RM. The file contains the analysis of gene family versus RM.

Format: XLSX Size: 160KB Download file

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Additional file 11:

Gene length versus RM. The file contains the analysis of gene length versus RM.

Format: XLSX Size: 27KB Download file

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Additional file 12:

Averaged multifractality versus Alus. The file contains averaged ΔDq versus averaged Alus per chromosome.

Format: XLSX Size: 10KB Download file

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Additional file 13:

Averaged multifractality versus CGI. The file contains averaged ΔDq versus averaged CGI per chromosome.

Format: XLSX Size: 16KB Download file

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Additional file 14:

Multifractality and hierarchical clustering analysis. The file contains the averaged multifractal parameters per chromosome for hierarchical clustering analysis.

Format: XLS Size: 36KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 15:

Chr 21 multifractal analysis by regions. The file contains multifractal parameters by averaged region of chromosome 21.

Format: XLSX Size: 12KB Download file

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Additional file 16:

Chrs X and Y multifractal analyses by regions. The file contains multifractal parameters by averaged region of chromosome X and Y.

Format: XLSX Size: 30KB Download file

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Additional file 17:

Chr 8 multifractal analysis by regions. The file contains multifractal parameters by averaged region of chromosome 8.

Format: XLSX Size: 26KB Download file

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Additional file 18:

Chr 1 multifractal analysis by regions. The file contains multifractal parameters by averaged region of chromosome 1.

Format: XLSX Size: 114KB Download file

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Additional file 19:

Chrs 4 and 19 multifractal analyses by regions. The file contains multifractal parameters by averaged region of chromosomes 4 and 19.

Format: XLSX Size: 34KB Download file

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Additional file 20:

Averaged CGI versus multifractality of chr. 1. The file contains averaged CGI versus averaged multifractality of chromosome 1.

Format: XLSX Size: 64KB Download file

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