Table 2

Enrichment analysis in the short-term hypercapnia microarray study on Carcinus maenas

Test-set

GO

name

FDR

Over-/Under- representation

down day 3

GO:0050794

regulation of cellular process

0.00

under

down day 3

GO:0007165

signal transduction

0.00

under

down day 3

GO:0023060

signal transmission

0.00

under

down day 3

GO:0023046

signaling process

0.00

under

down day 3

GO:0003824

catalytic activity

0.00

under

down day 3

GO:0050789

regulation of biological process

0.04

under

up day 3

no enrichment

-

-

-

down day 7

no enrichment

-

-

-

up day 7

no enrichment

-

-

-

up gill 7

GO:0007010

cytoskeleton organization

0.05

under

down gill 7

GO:0005623

cell

0.04

over

up gill 9

GO:0005198

structural molecule activity

0.03

over

down gill 9

no enrichment

-

-

-

Results of the enrichment analysis (Fisher's Exact Test with multiple testing correction; FDR < 0.05) as implemented in Blast2GO [43]. Tested were subsets of all significantly regulated transcripts as identified by sign test (up- and down-regulated separately for each gill and day or each combination of both). Reference-set in each analysis was the complete microarray sequence Blast2GO database generated from the contig list. GO = Gene Ontology term, name = GO name of the functional group, FDR = false discovery rate for correction of multiple testing, Over-/Underrepresentation = a GO term is considered over-/under-represented if it appears significantly more often/less often in the reference-set than it does in the test-set.

Fehsenfeld et al. BMC Genomics 2011 12:488   doi:10.1186/1471-2164-12-488