Open Access Research article

The Cryptosporidium parvum Kinome

Jennifer D Artz1*, Amy K Wernimont1, Abdellah Allali-Hassani1, Yong Zhao1, Mehrnaz Amani1, Yu-Hui Lin1, Guillermo Senisterra1, Gregory A Wasney1, Oleg Fedorov2, Oliver King2, Annette Roos2, Vlad V Lunin1, Wei Qiu1, Patrick Finerty1, Ashley Hutchinson1, Irene Chau1, Frank von Delft2, Farrell MacKenzie1, Jocelyne Lew1, Ivona Kozieradzki1, Masoud Vedadi1, Matthieu Schapira1, Chao Zhang3, Kevan Shokat3, Tom Heightman2 and Raymond Hui1

Author Affiliations

1 Structural Genomics Consortium, University of Toronto, MaRS South Tower, Floor 7, 101 College St, Toronto, Ontario M5G 1L7, Canada

2 Structural Genomics Consortium, University of Oxford, Old Road Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK

3 Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California 94158, USA

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BMC Genomics 2011, 12:478  doi:10.1186/1471-2164-12-478

Published: 30 September 2011

Additional files

Additional file 1:

Table S1 - Classification of the C. parvum protein kinases. Table listing the 73 protein kinases from C. parvum, showing the families, PDB depositions, and orthologues from data compiled from the sequence similarity within the kinase domain, their predicted orthologues, and a maximum likelihood tree from a rapid bootstrap analysis.

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Additional file 2:

Table S2 - Alignnments of C. parvum kinases. Excel sheet showing the alignment of the 73 protein kinase catalytic domains, as calculated by PROMALS3D multiple sequence and structure alignment server http://prodata.swmed.edu/promals3d/promals3d.php webcite. Table S3 - Alignment of select CaMK enzymes. Excel sheet showing the alignment of the kinase domains of select CaMK family members, as calculated by PROMALS3D multiple sequence and structure alignment server http://prodata.swmed.edu/promals3d/promals3d.php webcite.

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Additional file 3:

Table S4 - N-terminal latch of select CDPK enzymes. Table showing a partial sequence alignment of CDPK enzymes highlighting conserved N-terminal motifs implicated in binding the N-terminal latch. Table S5 - Gatekeepers in the C. parvum CDPK enzymes.

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