The 56-gene profiles correlate with developmental progress of keratinocytes. Correlation of the 56 genes was computed and plotted between the normal human skin and each sample from the dataset GSE6932 where NHEK cells were treated with PP-2 (open circle) or DMSO (cross) for various durations. The regression lines as well as the associated formula were also displayed with the plot. The slope of the regression line for the PP-2 treated NHEK is 0.0028 with p-value = 2 × 10-5 on t-test, compared with the DMSO control whose regression line has slope of 0.0005 with p-value = 0.0531.
Hwang et al. BMC Genomics 2011 12:439 doi:10.1186/1471-2164-12-439