Network analysis with the 56 genes and the mostly linked transcription factors. The gene network was built based on the algorithm "Receptor Targets Modeling" which identifies the important transcription factors (TFs) connected to the query genes and the signaling receptors associated with these TFs. Briefly, the algorithm at first builds two lists with the TFs or receptors which have direct links to the input objects and then draws shortest paths from each of the found receptors to each TF. Finally, a series of networks were generated as one network per receptor. Shown here is the highest ranked result. It suggests potential roles of the 56 genes in tissue development and tumorigenesis.
Hwang et al. BMC Genomics 2011 12:439 doi:10.1186/1471-2164-12-439