Table 4

Involvement of PKA in the transcriptional regulation of different classes of genes controlled by glucose

Class

Transcriptional

effect

Glucose added to strain

No glucose added

Representative

genes


PKA+

PKA-

PKA activated


1

Induction

+

+

-

PFK1, ENO2

Repression

+

+

-

CRC1, PCK1, MLS1

2

Induction

+

-

+

ARG3, THR4

Repression

+

-

+

GRX2, PEP4

3

Induction

+

+

+

HXT3, RPL7A, HOR2

Repression

+

+

+

ACS1, ADY2, CIT3

4

Induction

+

-

-

SDT1, STR3

Repression

+

-

-

HXT6, MDH1


The presence or absence of transcriptional response after addition of glucose to yeast strains with or without PKA activity is indicated by + or -. The column labelled "No glucose added" shows the transcriptional response when PKA is activated through an increase in cAMP that does not involve the presence of glucose [5].

Livas et al. BMC Genomics 2011 12:405   doi:10.1186/1471-2164-12-405

Open Data