Open Access Research article

Complete genome and comparative analysis of Streptococcus gallolyticus subsp. gallolyticus, an emerging pathogen of infective endocarditis

Dennis Hinse1, Tanja Vollmer1, Christian Rückert2, Jochen Blom3, Jörn Kalinowski2, Cornelius Knabbe1 and Jens Dreier1*

Author Affiliations

1 Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, 32545 Bad Oeynhausen, Germany

2 Institute for Genome Research and Systems Biology, Center for Biotechnology, Universität Bielefeld, Postfach 100131, 33501 Bielefeld, Germany

3 Bioinformatics Resource Facility, Center for Biotechnology, Universität Bielefeld, Postfach 100131, 33501 Bielefeld, Germany

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BMC Genomics 2011, 12:400  doi:10.1186/1471-2164-12-400

Published: 8 August 2011

Additional files

Additional file 1:

Pairwise synteny plot of the S. gallolyticus subsp. gallolyticus BAA-2069 and UCN34 genome. Every CDS of the first contig is checked for a reziprocal best blast hit. If one is found, the stopposition of both CDS are read from the database and used as coordinates for a dot.

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Additional file 2:

Unique genes of S. gallolyticus subsp. gallolyticus BAA-2069 in relation to S. gallolyticus subsp. gallolyticus UCN34. Unique genes calculated by EDGAR analysis.

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Additional file 3:

Unique genes of S. gallolyticus subsp. gallolyticus UCN34 in relation to S. gallolyticus subsp. gallolyticus BAA-2069. Unique genes calculated by EDGAR analysis.

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Additional file 4:

Core genome set of S. gallolyticus subsp. gallolyticus BAA-2069 and three Enterococcus feacalis strains. Following strains were used for calculation by EDGAR: E. faecalis 62 (Acc. No CP002491), E. faecalis OG1RF (Acc. no. CP002621) and E. faecalis V583 (Acc. no. NC_004668).

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Additional file 5:

Number of unique or common ORFs. Numbers represent the common or unique ORFs in comparison to BAA-2069 and indicated species.

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Additional file 6:

Agarose gel electrophoresis of restriction fragment pattern. Pattern were obtained with seven different enzymes, regarding plasmid pSGG2 (left lane) and pSGG1 (right lane). Ladder marker: 1 kb Ladder plus (Fermentas, St. Leon-Rot, Germany).

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Additional file 7:

Tetracycline susceptibility test. Minimum inhibitory concentration (MIC) was determined growth in liquid cultures with indicated tetracycline concentration.

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