Table 1

The DE genes associated with immune and inflammatory responses on PID 3

Functional

classification

Gene description

Gene symbol

Fold Change

Gen Bank ID


CD45 antigen isoform 3 Fragment

CD45

38.62459

AK230523

Sus scrofa antibacterial protein

PMAP-23

21.70289

EW419136

Sus scrofa peptide antibiotic PR39

PR39

13.50724

NM_214450

immune

Sus scrofa chemokine ligand 26-like mRNA

CCL26

8.645769

NM_001078665

response

Sus scrofa protegrin 4 NPG4, mRNA

NPG4

8.237142

NM_213863

Sus scrofa immunoglobulin kappa variable group

IGKV

6.440473

CB286369

Sus scrofa 2'-5'-oligoadenylate synthetase-like mRNA

OASL

5.803129

NM_001031790

Interferon-stimulated gene 20 kDa protein

ISG20

5.414398

NM_001005351.2

Sus scrofa chemokine C-X-C motif ligand 10 mRNA

CXCL10

5.329808

NM_001008691

Rep: IL-1 receptor 2-Bos taurus Bovine, partial 98%

IL1R2

5.321422

NM_001046210.1

Sus scrofa MHC class II histocompatibility antigen

SLA-DQA1

5.232868

AK230483

Sus scrofa cathepsin L1-like

CTSL1

4.814094

AK230898

Sus scrofa interferon regulatory factor 3 (IRF3), mRNA

IRF3

4.320395

NM_213770

Sus scrofa Fc fragment of IgG, low affinity IIb, receptor, mRNA

FCGR2B

3.622257

NM_001033013

Sus scrofa CD14 molecule, mRNA

CD14

3.544918

NM_001097445

Sus scrofa interferon stimulated gene 15 mRNA

ISG15

3.45

EU584557.1

Sus scrofa IgG heavy chain LOC396781, mRNA

IgG

3.438582

NM_213828

Sus scrofa interferon-induced protein with tetratricopeptide repeats 1

IFI56

3.386147

XM_001928724

Sus scrofa inducible T-cell co-stimulator ICOS, mRNA

ICOS

3.353116

NM_001044546

Sus scrofa interferon regulatory factor 7 IRF7, mRNA

IRF7

3.249327

NM_001097428

Sus scrofa myxovirus influenza virus resistance 1, interferon-inducible protein p78 MX1, mRNA

MX1

3.237013

NM_214061

Sus scrofa MHC class I antigen

SLA-2

3.187732

AK231553

Sus scrofa cytotoxic T-lymphocyte-associated protein 4 CTLA4, mRNA

CTLA4

3.184663

NM_214149

Sus scrofa DEAD Asp-Glu-Ala-Asp box polypeptide 58 DDX58, mRNA

DDX58

3.122048

NM_213804

Rep:Tumor necrosis factor receptor superfamily member 17-Homo sapiens

TNFRSF17

3.071191

NM_001192.2

Sus scrofa CD8a molecule CD8A, mRNA

CD8A

2.834259

NM_001001907

Similar to melanoma cell adhesion molecule

CD146

-2.819245

BX915975

similar to guanylate binding protein 4

GBP4

2.780124

AK239735

Sus scrofa guanylate binding protein 1, interferon-inducible, 67 kDa GBP1, mRNA

GBP1

2.765026

NM_001128473

Sus scrofa ubiquitin specific peptidase 18, mRNA

USP18

2.732302

NM_213826

Sus scrofa interferon-induced protein with tetratricopeptide repeats 2 mRNA

IFI54

2.729199

AK230663

mast cell immunoreceptor signal transducer-like

CLNK

2.704822

AK237804

Rep:CD274 molecule CD274, mRNA- Homo sapiens

CD274

2.648947

EW655654

Sus scrofa CD163 molecule CD163, mRNA

CD163

2.633336

NM_213976

Sus scrofa interferon-induced protein 44 mRNA

IFI44

2.629777

AK233687

Sus scrofa interleukin 12A natural killer cell stimulatory factor 1, IL12A, mRNA

IL12A

2.580563

NM_213993

Sus scrofa guanylate binding protein 2, interferon-inducible GBP2, mRNA

GBP2

2.561492

NM_001128474

Sus scrofa interferon-induced protein with tetratricopeptide repeats 3, mRNA

IFI60

2.465327

XM_001928703

Sus scrofa interferon-induced transmembrane protein 1

IFITM1

2.407903

AK237820

Sus scrofa chemokine C-C motif receptor 5, mRNA

CCR5

2.374719

NM_001001618

Sus scrofa chemokine C-C motif receptor 10, mRNA

CCR10

2.36215

NM_001044563

Sus scrofa chemokine C-C motif ligand 28, mRNA

CCL28

2.330211

NM_001024695

Sus scrofa chemokine C-X-C motif ligand 9 mRNA

CXCL9

2.312722

BP169836

Sus scrofa transporter 1, ATP-binding cassette, sub-family B MDR/TAP TAP1, mRNA

TAP1

2.15635

NM_001044581

Sus scrofa Fas ligand TNF superfamily, member 6, mRNA

FAS

2.098484

NM_213806

Sus scrofa immunoglobulin-associated alpha CD79A, mRNA

CD79A

2.086904

NM_001135962

Sus scrofa interferon induced with helicase C domain 1 IFIH1, mRNA

IFIH1

2.075703

NM_001100194

Sus scrofa aquaporin 9, mRNA

AQP9

2.067154

NM_001112684

Sus scrofa tumor necrosis factor superfamily member 18 mRNA, partial cds

TNFSF18

2.065184

DQ995649

Sus scrofa 2'-5'-oligoadenylate synthetase 2, 69/71kDa OAS2, mRNA

OAS2

2.054377

NM_001031796

similar to cystatin F

CST7

2.042642

CJ009409

Sus scrofa Ig gamma 2b chain constant region

IGG2B

2.017483

AK237225

Sus scrofa CD86 molecule CD86, mRNA

CD86

2.007655

NM_214222

Sus scrofa vitronectin VTN, mRNA

VTN

-2.006228

NM_214104

Sus scrofa chemokine ligand 26-like protein LOC780409, mRNA

CCL26

8.645769

NM_001078665

Sus scrofa Toll-like receptor 3

TLR3

7.331916

NM_001097444.1

Sus scrofa chemokine C-X-C motif ligand 10, mRNA

CXCL10

5.329808

NM_001008691

Sus scrofa selectin L (SELL), mRNA

SELL

4.497706

NM_001112678

inflammatory

Sus scrofa inflammatory response protein 6, mRNA

IRG6

3.840661

NM_213817

response

Sus scrofa C1q-related factor LOC780424, mRNA

CRF

3.627351

NM_001078676

Sus scrofa CD14 molecule CD14, mRNA

CD14

3.544918

NM_001097445

Sus scrofa alpha-1-antichymotrypsin 2 SERPINA3-2

SERPINA3

3.119463

NM_213787

Sus scrofa complement C4 C4, mRNA

C4

2.949702

NM_001123089

Sus scrofa selectin E SELE, mRNA

SELE

-2.879741

NM_214268

Sus scrofa toll-like receptor 2 (TLR2), mRNA

TLR2

2.8723

NM_213761

Similar to melanoma cell adhesion molecule

CD146

-2.819245

BX915975

Sus scrofa toll-like receptor 8 TLR8, mRNA

TLR8

2.675719

NM_214187

Sus scrofa CD163 molecule CD163, mRNA

CD163

2.633336

NM_213976

Rep: transforming growth factor, beta 2- Macaca mulatta

TGFB2

-2.554227

EV858461

Sus scrofa chemokine C-C motif receptor 5, mRNA

CCR5

2.374719

NM_001001618

Sus scrofa chemokine C-C motif ligand 28, mRNA

CCL28

2.330211

NM_001024695

Sus scrofa chemokine C-X-C motif ligand 9

CXCL9

2.312722

BP169836

Sus scrofa serpin peptidase inhibitor, clade E member 1 SERPINE1, mRNA

SERPINE1

2.225002

NM_213910

Sus scrofa Toll-like receptor 9 TLR9, mRNA

TLR9

2.200666

NM_213958

Rep: arachidonate 15-lipoxygenase Alox15 gene- Mus musculus

Alox15

-2.168114

AK238353

Sus scrofa signal transducer and activator of transcription 1 STAT1, mRNA

STAT1

2.116864

NM_213769

Sus scrofa S100 calcium binding protein A2

S100A2

2.04835

XM_001929556

Sus scrofa serpin peptidase inhibitor, clade G1 inhibitor, member 1 SERPING1, mRNA

SERPING1

2.022489

NM_001123194


The DE genes associated with immune and inflammatory responses were assigned based on GO term and manual annotation. Manual annotations were listed in italics. Most genes could also be classified into other categories but only immune and inflammatory responses were considered.

Li et al. BMC Genomics 2011 12:398   doi:10.1186/1471-2164-12-398

Open Data