Table 3

Significantly over-represent transcription factor module families in TCDD-induced AhR enriched regionsa.

TF Module Family

Module Description

2 hr AhR enriched regions

24 hr AhR enriched regions



# of matches

Expected # of matches

Over-representaionb

Z-Score

# of matches

Expected # of matches

Over-representaionb

Z-Score


AHR

AhR-ARNT heterodimer

9,447

4,278.30

2.21

79.03

851

297.44

2.86

32.07

SP1

GC-Box factors SP1/GC

19,356

12,839.04

1.51

57.54

1,346

892.61

1.51

15.17

HIF

Hypoxia inducible factor, bHLH/PAS protein family

8,763

4,841.13

1.81

56.37

569

336.57

1.69

12.64

E2F

E2F-Myc activator/cell cycle regulator

18,247

12,444.88

1.47

52.04

1,266

865.21

1.46

13.62

ZBP

Zinc binding protein factors

25,542

18,518.20

1.38

51.65

1,739

1,287.45

1.35

12.58

NRF1

Nuclear respiratory factor 1

3.475

1,494.81

2.32

51.21

252

103.92

2.42

14.48

ZF5

ZF5 POZ domain zinc finger

3,156

1,442.92

2.19

45.09

205

100.32

2.04

10.40

NF1

Nuclear factor 1

13,047

8,876.90

1.47

44.27

886

617.15

1.44

10.81

NR2F

Nuclear receptor subfamily 2 factors

44,774

36,390.64

1.23

44.02

3,180

2,530.00

1.26

12.93

EGR

EGR/nerve growth factor included protein c

22,224

16,794.62

1.32

41.92

1,541

1,167.62

1.32

11.

PPAR

Peroxisome proliferator-activated receptor

24,808

19,035.70

1.30

41.87

1,752

1,323.43

1.32

11.78

RXR

RXR heterodimer binding sites

41,027

33,441.00

1.23

41.54

2,932

2,324.93

1.26

12.60

WHN

Winged helix binding sites

3,030

1,477.23

2.05

40.39

206

102.70

2.01

10.14


a AhR enriched regions with a FDR < 0.01

b total number of matches in enriched regions/expected number of matches in genome

Complete list of over-represented TF module families are provided in Additional Files 6 and 7

Dere et al. BMC Genomics 2011 12:365   doi:10.1186/1471-2164-12-365

Open Data