Figure 2.

Characterization of TCDD-induced AhR enriched regions at 2 and 24 hrs (FDR < 0.01). Frequency analysis of enriched regions relative to log₂ fold enrichment at 2 hr (A) and 24 hr (B) illustrating enrichment values in intragenic (light green) and intergenic (dark green) DNA regions. Distribution of enriched regions relative to region width (C) at 2 hrs (light red) and 24 hrs (dark red) identified 90.5% of enriched sites were ≤ 1,500 bp. Comparison of AhR enriched regions at 2 and 24 hrs identified 899 overlapping regions (D). Analysis of the fold enrichment values for the 899 overlapping regions at 2 and 24 hrs identified a positive correlation (two-tailed P-value < 0.0001, Pearson correlation coefficient = 0.4853; E).