Coevolution of translation initiation signals and operons. Each bacterial genome is denoted by two points in the figure (black and red), while each archaeal genome is denoted by a green point and a blue point. The proportion of operon distal genes is positively correlated to SD-led genes while negatively correlated to TA-led genes in both bacteria and archaea. Linear regressions are y = 0.61-0.40x (black, R = -0.26), y = 0.48+0.22x (red, R = 0.51), y = 0.57-0.30x (green, R = -0.73) and y = 0.36+0.25x (blue, R = 0.76), all p-value < 0.0001.
Zheng et al. BMC Genomics 2011 12:361 doi:10.1186/1471-2164-12-361