Table 3

Functional analysis of EGF responsive pathways.

ID

name

genes

regulated genes

connections


1

05200

Pathways in cancer

265

31

139

2

04510

Focal adhesion

156

17

97

3

04660

T cell receptor signaling pathway

80

7

69

4

05215

Prostate cancer

74

7

65

5

04662

B cell receptor signaling pathway

59

6

63

6

04010

MAPK signaling pathway

203

25

62

7

05210

Colorectal cancer

55

6

61

8

05222

Small cell lung cancer

76

12

60

9

04012

ErbB signaling pathway

74

9

60

10

04722

Neurotrophin signaling pathway

104

9

60

11

05220

Chronic myeloid leukemia

64

7

59

12

04810

Regulation of actin cytoskeleton

163

14

46

13

05214

Glioma

55

5

44

14

05211

Renal cell carcinoma

58

9

44

15

05223

Non-small cell lung cancer

51

6

42

16

05142

Chagas disease

71

5

41

17

04310

Wnt signaling pathway

118

7

41

18

05219

Bladder cancer

35

5

37

19

05140

Leishmaniasis

42

4

36

20

04620

Toll-like receptor signaling pathway

59

4

36

21

04912

GnRH signaling pathway

70

6

35

22

04210

Apoptosis

74

8

32

23

04916

Melanogenesis

76

3

30

24

04630

Jak-STAT signaling pathway

94

12

27

25

05410

Hypertrophic cardiomyopathy (HCM)

60

7

27

26

05414

Dilated cardiomyopathy

65

7

27

27

04115

p53 signaling pathway

58

11

25

28

04621

NOD-like receptor signaling pathway

40

6

25

29

05412

Arrythmogenic right ventricular cardiomyopathy (ARVC)

52

6

25

30

04920

Adipocytokine signaling pathway

55

6

24

31

04120

Ubiquitin mediated proteolysis

120

15

22

32

04370

VEGF signaling pathway

57

3

21

33

04060

Cytokine-cytokine receptor interaction

132

14

18

34

04640

Hematopoietic cell lineage

43

7

16

35

04530

Tight junction

97

7

16

36

04340

Hedgehog signaling pathway

39

3

15

37

04622

RIG-I-like receptor signaling pathway

46

4

15

38

04360

Axon guidance

105

9

14

39

05217

Basal cell carcinoma

41

1

12

40

04144

Endocytosis

162

13

11

41

05014

Amyotrophic lateral sclerosis (ALS)

41

3

8

42

04350

TGF-beta signaling pathway

69

6

6

43

00561

Glycerolipid metabolism

38

4

5

44

00564

Glycerophospholipid metabolism

59

4

5

45

00600

Sphingolipid metabolism

27

4

4

46

04070

Phosphatidylinositol signaling system

66

4

4

47

00562

Inositol phosphate metabolism

50

3

3

48

00565

Ether lipid metabolism

20

1

3

49

05020

Prion diseases

22

3

3

50

04710

Circadian rhythm - mammal

20

4

2

51

00601

Glycosphingolipid biosysnthesis - lacto and neolacto series

21

2

0

52

00532

Glycosaminoglycan biosynthesis - chondroitin sulphate

17

2

0

53

00760

Nicotinate and nicotinamide metabolism

17

4

0

54

00750

Vitamin B6 metabolism

5

1

0

55

00790

Folate biosynthesis

9

0

0


List of GlobalAncova derived differentially expressed KEGG functions upon EGF treatment indicating the total number of genes, the number of regulated genes and the number of connections (shared regulated genes) to other pathways. The number identifying each KEGG category are the same used for the nodes in the graph on Figure 7.

Llorens et al. BMC Genomics 2011 12:326   doi:10.1186/1471-2164-12-326

Open Data