Table 2

Transcripts down regulated by Se deficiency

Genbank Accession

Gene Symbol

Gene Title

Fold Change1

adj P-value2

Nrf2 Target3


Mouse Liver

NM_009156

Sepw1

selenoprotein W, muscle 1

-3.73

1.7E-05

NM_001033166

Selh

selenoprotein H

-2.83

0.0009

NM_008160

Gpx1

glutathione peroxidase 1

-2.14

0.0001

NM_019979

Selk

selenoprotein K

-2.14

0.0012

NM_013711

Txnrd2

thioredoxin reductase 2

-1.64

0.0091

- - - - - - - - - - - - - - - - - - - - - - - - -

NM_015762

Txnrd1

thioredoxin reductase 1

-1.57

0.099

X

Mouse Kidney

NM_001033166

Selh

selenoprotein H

-2.64

0.0004

NM_009156

Sepw1

selenoprotein W, muscle 1

-2.64

0.0044

NM_008160

Gpx1

glutathione peroxidase 1

-2.46

0.0039

- - - - - - - - - - - - - - - - - - - - - - - - -

Rat Liver4

NM_001114939

Selh

selenoprotein H

-6.06

< 0.001

NM_030826

Gpx1

glutathione peroxidase 1

-3.73

< 0.001

NM_001014253

Selt

selenoprotein T

-1.60

0.005

NM_001106609

Txnrd3

thioredoxin reductase 3

-1.60

0.03

- - - - - - - - - - - - - - - - - - - - - - - - -

NM_022584

Txnrd2

thioredoxin reductase 2

-1.57

0.06

NM_207589

Selk

selenoprotein K

-2.46

0.07


Transcripts that were significantly (above dashed line, P < 0.05) or nearly significantly (below dashed line, 0.05 < P < 0.2) down-regulated in Se-deficient rodent tissues compared to Se-adequate (0.2 or 0.24 μg Se/g diet, for mouse and rat studies respectively). 1Fold changes determined by analysis of RMA expression data with the Limma package in R software, 2P-values were adjusted for multiple testing, 3Genes known to be Nrf2 targets, determined as described in the text, 4Genes down-regulated in Se-deficient liver from rats in study 2.

Raines and Sunde BMC Genomics 2011 12:26   doi:10.1186/1471-2164-12-26

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