Table 4

Polar metabolites significantly affected by TCDD exposure.

Metabolite

Change fold (1H NMR p < 0.01)

Change fold (LC-MS p < 0.01)


Leucine, Isoleucine

0.69

0.64

Valine

0.72

0.69

Alanine

0.68

--

N-acetyl-aspartate

0.68

0.72

Glutamate

0.79

0.80

Glutamine

0.69

--

Glycine

0.72

--

Aspartate

0.66

--

Serine

0.65

--

Tyrosine

0.58

0.44

Proline

--

0.54

Tryptophan

--

0.79

Lactate

0.49

--

Spermidine

--

0.24

N1-acetyl-spermidine

--

0.59

Pantothenic acid

--

0.62

Creatine/Phosphocreatine

0.66

--

Propyonylcarnitineb

--

0.66

Butyrylcarnitine

--

0.58

Nucleotides (AXP and UMP)

0.3-0.6

--

UMP

--

0.71

AMP

--

0.67


Oxidized glutathione

1.26

1.31

Reduced glutathione

1.58

1.23

Taurine

1.37

--

Citrate

1.46

1.68

UDP-N-acetyl-galactosamine/glucosamine*

--

1.48


The fold changes are given as the ratio of the average content in TCDD and in DMSO. Individual passage number results are in Additional File 1 (Tables S5 and S6).

*Tentatively identified

Ruiz-Aracama et al. BMC Genomics 2011 12:251   doi:10.1186/1471-2164-12-251

Open Data