Table 4 |
||
|
Polar metabolites significantly affected by TCDD exposure. |
||
|
Metabolite |
Change fold (1H NMR p < 0.01) |
Change fold (LC-MS p < 0.01) |
|
|
||
|
Leucine, Isoleucine |
0.69 |
0.64 |
|
Valine |
0.72 |
0.69 |
|
Alanine |
0.68 |
-- |
|
N-acetyl-aspartate |
0.68 |
0.72 |
|
Glutamate |
0.79 |
0.80 |
|
Glutamine |
0.69 |
-- |
|
Glycine |
0.72 |
-- |
|
Aspartate |
0.66 |
-- |
|
Serine |
0.65 |
-- |
|
Tyrosine |
0.58 |
0.44 |
|
Proline |
-- |
0.54 |
|
Tryptophan |
-- |
0.79 |
|
Lactate |
0.49 |
-- |
|
Spermidine |
-- |
0.24 |
|
N1-acetyl-spermidine |
-- |
0.59 |
|
Pantothenic acid |
-- |
0.62 |
|
Creatine/Phosphocreatine |
0.66 |
-- |
|
Propyonylcarnitineb |
-- |
0.66 |
|
Butyrylcarnitine |
-- |
0.58 |
|
Nucleotides (AXP and UMP) |
0.3-0.6 |
-- |
|
UMP |
-- |
0.71 |
|
AMP |
-- |
0.67 |
|
|
||
|
Oxidized glutathione |
1.26 |
1.31 |
|
Reduced glutathione |
1.58 |
1.23 |
|
Taurine |
1.37 |
-- |
|
Citrate |
1.46 |
1.68 |
|
UDP-N-acetyl-galactosamine/glucosamine* |
-- |
1.48 |
|
|
||
|
The fold changes are given as the ratio of the average content in TCDD and in DMSO. Individual passage number results are in Additional File 1 (Tables S5 and S6). *Tentatively identified |
||
|
Ruiz-Aracama et al. BMC Genomics 2011 12:251 doi:10.1186/1471-2164-12-251 |
||
