Comparing miRNA orthologues. Composite plots summarising the enrichment scoring of all possible hexameric queries given the respective hsa-miR-155 (Panel A) and KSHV-miR-k12-11 (Panel B) differential expression profiles. In each instance the highest scoring hexamer is highlighted in turquoise while the highest scoring seed hexamer is highlighted in red. Note how the hsa-miR-155 profile is dominated by AT-rich transcripts and that there is minimal enrichment of the miRNA target motif. The paucity of significant motifs in the KSHV-miR-k12-11 plot highlight that few transcripts are differentially expressed relative to the control dataset. Also note that the seed region is conserved in both miRNAs.
Wilson and Plucinski BMC Genomics 2011 12:250 doi:10.1186/1471-2164-12-250