Table 2

Orthology relationships among ePKs of S. mansoni, B. malayi, and C. elegans and RNAi phenotype for C. elegans proteins

Group

S. mansoni

C. elegans

Brugi malayi

C. elegans RNAi phenotype


CaMK

Smp_053560

C44C8.6_Ce e K08F8.1

-

Embryonic Lethal

AGC

Smp_123640

F19C6.1_Ce

-

Embryonic lethal, maternal sterile, organism morphology variant.

Smp_136750

Y47D3A.16_Ce

Bm1_44635

Larval lethal, fertility reduced

Smp_158560

K08B12.5_Ce

Bm1_02320

Body morphology defect, slow growth

Smp_096310

pkc-3_Ce_A

Bm1_03335

Embryonic lethal, sterile, body morphology defect

TK

Smp_139480

vab-1_Ce_T

Bm1_03410

Embryonic lethal, body morphology defect

STE

Smp_026510, Smp_151670

mek-2_Ce

-

Embryonic lethal, sterile, reduced brood size, exploted through vulva, slow growth

Smp_096640

gck_1_Ce

-

cortical dynamics defective early embryonic, maternal sterile

Smp_163420

mig_15_Ce

Bm1_32540

Abnormal cell migration, protruding vulva, developmental delay

Smp_068060

kin_18_Ce

Bm1_55590

Embryonic lethal, body morphology defect, slow growth, sterile, larval lethal, dumpy

Smp_131800

Y59A8B.23_CE

Bm1_11845

More depolarized oocytes

Smp_150260

C04A11.3_Ce

Bm1_26435

Slow growth, larval lethal late L3/L4

TKL

Smp_079760

pat4_Ce_TK

Bm1_20815

Embryonic lethal, body morphology defect, larval lethal, sterile,

paralyzed, uncoordinated movement, paralyzed

Smp_176990

lin45_Ce_T

Bm1_40290

Sterile, osmotic integrity problems

CMGC

Smp_068960

F22D6.5_Ce

Bm1_12230

Embryonic lethal, slow growth, sterile progeny, uncoordinateed movement

Smp_041770

spk_1_Ce

-

Embryonic lethal, larval lethal, maternal sterile

Smp_172700

cdk_4_Ce

-

Locomotion variant, larval lethal, sterile progeny

Smp_133020

pmk-1_Ce, pmk-2_Ce

-

Apoptosis increased, sterile progeny, reduced brood size, embryonic lethal

Smp_134260, Smp_133490, Smp_133500

C05D10.2

-

Reduced brood size, embryonic lethal

Smp_080730

cdk_1_Ce

-

embryonic lethal, sterile progeny

Smp_155720, Smp_125310, Smp_008260.1

Y18D10A.5_Ce, C44H4.6_Ce

-

Larval lethal, slow growth, embryonic lethal

Smp_156990

F39H11.3_Ce

Bm1_33825

Sterile

Smp_176620

B0495.2_Ce, ZC504.3_Ce

Bm1_17240

Embryonic lethal

Smp_003000

H25P06.2_Ce

-

Embryonic lethal, slow growth, uncoordinated movement

Smp_150040

Cdk_7_Ce

Bm1_14135

Embryonic lethal

Smp_140700, Smp_074080

lit_1_Ce

Bm1_130

Embryonic lethal, larval lethal

Smp_141230

mbk_2_Ce

Bm1_38345

Embryonic lethal, sterile progeny


Orthology relationships were inferred based on phylogenetic trees. RNAi phenotype for C. elegans were visualized by recent work [68] that relied on identification and analysis of essential genes.

Andrade et al. BMC Genomics 2011 12:215   doi:10.1186/1471-2164-12-215

Open Data