Additional file 9.

Phylogenetic analysis of the TKL group. Amino acid sequences of the catalytic domain of the CK1 proteins of S. mansoni (blue labels), C. elegans, D. melanogaster, S. cerevisiae, H. sapiens, and B. malayi were used to construct a distance-based phylogenetic tree using PHYLIP programs. Bootstrap values (1000 replicates) equal or higher than 80% are indicated (‚óŹ) as cutoff values to support the family/subfamily classification. Functional classification is indicated individually in the protein labels. Protein families are highlighted by the vertical bars and include: IRAK (IL1 Receptor Associated Kinase), RIPK (Receptor Interacting Protein Kinases), LISK (Family containing closely related TESK and LIMK sub-families), MLK (Miked Lineage Kinases), LRRK (Leucine Rich Repeat Kinase), RAF, STKR (Serine/Threonine Kinase Receptors - receptors for activin and TGFb ligands).

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Andrade et al. BMC Genomics 2011 12:215   doi:10.1186/1471-2164-12-215