Additional file 7.
Phylogenetic analysis of the TK group. Amino acid sequences of the catalytic domain of the TK proteins of S. mansoni (blue labels), C. elegans, D. melanogaster, S. cerevisiae, H. sapiens, and B. malayi were used to construct a distance-based phylogenetic tree using PHYLIP programs. Bootstrap values (1000 replicates) equal or higher than 80% are indicated (●) as cutoff values to support the family/subfamily classification. Functional classification is indicated individually in the protein labels. Protein families are highlighted by the vertical bars and include: JAK, Ack (Activated Cdc42-associated tyrosine kinase), Syk, FAK (Focal Adhesion Kinase), VKR, Fer, Sev, ALK (Anaplastic Lymphoma Kinase), InsR (Insulin Receptor), DDR (Discoidin Domain Receptor kinase), Musk (Muscle-Specific Kinase), Ror, Lmr (Lemur Kinase), Eph (Ephrin receptors), Axl (Also known as TAM (Tyro3, Axl, Mer)), Ryk, EGFR (Epidermal Growth Factor Receptor), FGFR (Fibroblast Growth Factor Receptor), PDGFR, VEGFR, Kin16, Jak (Janus Kinases), Tec, Abl (Abelson murine leukemia homolog), and Src.
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Andrade et al. BMC Genomics 2011 12:215 doi:10.1186/1471-2164-12-215