Additional file 5.
Phylogenetic analysis of the CMGC group. Amino acid sequences of the catalytic domain of the CMGC proteins of S. mansoni (blue labels), C. elegans, D. melanogaster, S. cerevisiae, H. sapiens, and B. malayi were used to construct a distance-based phylogenetic tree using PHYLIP programs. Bootstrap values (1000 replicates) equal or higher than 80% are indicated (●) as cutoff values to support the family/subfamily classification. Functional classification is indicated individually in the protein labels. Protein families are highlighted by the vertical bars and include: GSK (Gycogen Synthase 3 Kinase), MAPK (Mitogen Activated Protein Kinase), CK2 (Cell Kinase 2), CDKL (Cyclin Dependent Kinase Like), CDK (Cyclin Dependent Kinase), SRPK (SR Protein Kinase; phosphorylates SR splicing factors), DYRK (Dual-specificity Y (tyrosine) Regulated Kinase), CLK (CDC-Like Kinase).
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Andrade et al. BMC Genomics 2011 12:215 doi:10.1186/1471-2164-12-215